Results 31 to 40 of about 266,619 (234)

Flux predictions of high-energy neutrinos from pulsars [PDF]

, 2006
Young, rapidly rotating neutron stars could accelerate ions from their surface to energies of $\sim 1$ PeV. If protons reach such energies, they will produce pions (with low probability) through resonant scattering with x-rays from the stellar surface ...
Arons, Bennett Link, Carr, Cordes, Dai, Distefano, Fiorella Burgio, Gaisser, Goldreich, Halzen, Learned, Link, Manchester, Pavlov, Pavlov, Protheroe, Ruderman, Slane, Waxman, Weisskopf   +19 more
core   +4 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Stars, Dust, and the Growth of UV-Selected Sub-L* Galaxies at Redshift z~2

, 2011
[Abridged] This work concerns very faint (R_lim=28 AB mag; M_(stars, lim) ~ 10^8 Msun), UV-selected sub-L* BX galaxies at z~2.3. Stellar masses, dust content, and dust-corrected SFRs are constrained using broadband SED fitting, giving insights into the ...
Adelberger, Adelberger, Adelberger, Adelberger, Arnouts, Behroozi, Bertin, Best, Bouché, Bouwens, Bruzual, Calzetti, Cole, Cowie, Croton, Daddi, Daddi, Dekel, Dickinson, Elsner, Erb, Fontana, Franx, Förster Schreiber, Gabasch, Garn, Giavalisco, Giavalisco, Glazebrook, Hall, Hogg, Iwata, Kauffmann, Komatsu, Kroupa, Krumholz, Lee, Lee, Lilly, Madau, Maraston, Marcin Sawicki, Meurer, Ohta, Oke, Ouchi, Papovich, Papovich, Pettini, Pérez-González, Reddy, Reddy, Reddy, Salpeter, Savoy, Sawicki, Sawicki, Sawicki, Sawicki, Sawicki, Sawicki, Sawicki, Sawicki, Sawicki, Schechter, Shapley, Shapley, Sorba, Steidel, Steidel, Steidel, Steidel, Thompson, Tilvi, Vijh, Williams, Wright, Wyder, Yabe, Yuma, Yuma   +80 more
core   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Detectors for the James Webb Space Telescope Near-Infrared Spectrograph I: Readout Mode, Noise Model, and Calibration Considerations

, 2007
We describe how the James Webb Space Telescope (JWST) Near-Infrared Spectrograph's (NIRSpec's) detectors will be read out, and present a model of how noise scales with the number of multiple non-destructive reads sampling-up-the-ramp.
Augustyn Waczynski, Bacon C. M., Bernard J. Rauscher, Brent Mott, Bryan Howe, Cheryl Marshall, Chuck Engler, Clifford K. Brambora, Craig Cabelli, David Alexander, Donald N. B. Hall, Donna Wilson, Edward Cheng, Gardner J. P., Ginn Lee, Guido De Marchi, James Garnett, James York, James M. Marsh, Janesick J. R., John Nieznanski, Kamdin B. Shakoorzadeh, Klaus W. Hodapp, Majid Zandian, Markus Loose, Matthew B. Garrison, Michael W. Regan, Miles Smith, Miriam Jurado, Ori Fox, Paolo Strada, Peter Jakobsen, Peter Wallis, Pierre Ferruit, Rebecca Derro, Robert J. Hill, Robert J. Martineau, Selmer Wong‐Anglin, Sridhar S. Manthripragada, Thomas Johnson, Timothy Ellis, Torsten Böker, Wayne D. Roher, Wei Xia‐Serafino, Yiting Wen   +44 more
core   +1 more source

Spread spectrum-based video watermarking algorithms for copyright protection [PDF]

, 2002
Merged with duplicate record 10026.1/2263 on 14.03.2017 by CS (TIS)Digital technologies know an unprecedented expansion in the last years. The consumer can now benefit from hardware and software which was considered state-of-the-art several years ago ...
Serdean, Cristian Vasile
core   +2 more sources

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source