Results 41 to 50 of about 266,619 (234)

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

The Anti-Coincidence Detector for the GLAST Large Area Telescope [PDF]

, 2007
This paper describes the design, fabrication and testing of the Anti-Coincidence Detector (ACD) for the Gamma-ray Large Area Space Telescope (GLAST) Large Area Telescope (LAT).
Amato, M. J., Hartman, R. C., Johnson, T. E., Moiseev, A. A., Ormes, J. F., Segal, K. N., Sheppard, D. A., Thompson, D. J.   +7 more
core   +4 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Diffuse high energy neutrinos and cosmic rays from hyperflares of soft-gamma repeaters

, 2009
We calculate the diffuse high energy (TeV - PeV) neutrino emission from hyperflares of Soft-Gamma Repeaters (SGRs), like the hyperflare risen from \astrobj{SGR 1806-20} on December 27 of 2004, within the framework of the fireball model.
Abbasi, Achterberg, Ahrens, Ahrens, Asano, Asano, Atoyan, Axford, Bahcall, Becker, Berezhko, Budnik, Cameron, Clark, Corbel, Dai, Dermer, Dermer, Distefano, Duncan, Eikenberry, Fan, Frederiks, Fuchs, Gaensler, Gaensler, Gehrels, Guetta, Halzen, Hurley, Ioka, Katz, Kohnle, Lazzati, Levinson, Lorimer, Mazets, Muno, Muno, Murase, Mészáros, Mészáros, Mészáros, Nakar, Nakar, Palmer, Piran, Popov, Razzaque, Stecker, Tan Lu, Taylor, Terasawa, Thompson, Vietri, Wachter, Wang, Wang, Waxman, Waxman, Woods, Xue-Feng Wu, Xue-Wen Liu, Yamazaki, Zhang   +64 more
core   +1 more source

Evolutionary dynamics of the chloroplast genome in Daphne (Thymelaeaceae): comparative analysis with related genera and insights into phylogenetics

FEBS Open Bio, EarlyView.
Comparative analysis of chloroplast genomes from 14 genera of Thymelaeaceae revealed variation in gene content, ranging from 128 to 142 genes, primarily influenced by IR expansion/contraction events and pseudogenization of ndhF, ndhI, and ndhG. Two large inversions were detected within the large single‐copy region, including a synapomorphic inversion ...
Abdullah, Hui Li, Rushan Yan, Chengyu Chen, Madiha Islam, Abdul Majid, Ibrar Ahmed, Parviz Heidari, Xiaoxuan Tian   +8 more
wiley   +1 more source

PHIBSS: molecular gas content and scaling relations in z~1-3 normal star forming galaxies

, 2012
We present PHIBSS, the IRAM Plateau de Bure high-z blue sequence CO 3-2 survey of the molecular gas properties in normal star forming galaxies (SFGs) near the cosmic star formation peak.
Bolatto, A., Bournaud, F., Burkert, A., Combes, F., Comerford, J., Cooper, M. C., Cox, P., Davi, M., García-Burillo, S., Genzel, R., Gracia-Carpio, J., Griffin, K. Shapiro, Lutz, D., Naab, T., Neri, R., Newman, S., Omont, A., Saintonge, A., Schreiber, N. M. Förster, Shapley, A., Sternberg, A., Tacconi, L. J., Weiner, B., Wuyts, S.   +23 more
core   +3 more sources

Mu + N --> Tau + N at a Muon or Neutrino Factory [PDF]

, 2003
The experimental discovery of large nu_mu-nu_tau mixing indicates that analogous mixing in the charged lepton sector could be substantial. We consider the possibility that if a high intensity muon beam, perhaps at the early stages of a muon or neutrino ...
Sher, Marc, Turan, Ismail
core   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

Dilaton as a Dark Matter Candidate and its Detection

, 2007
Assuming that the dilaton is the dark matter of the universe, we propose an experiment to detect the relic dilaton using the electromagnetic resonant cavity, based on the dilaton-photon conversion in strong electromagnetic background.
E. Kolb, J. H. Kim, J. D. Jackson, M. Green, P. Jordan, S. Asztalos, W. Greiner, W. Pauli, Y. M. Cho, Y. M. Cho, Y. M. Cho   +10 more
core   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source