Results 191 to 200 of about 62,874 (268)

Ultrafast scintillating metal-organic framework films. [PDF]

Nat Commun
Dhamo L, Perego J, Villa I, Bezuidenhout CX, Mattei I, Landella A, Bracco S, Comotti A, Monguzzi A.   +8 more
europepmc   +1 more source

Cryo‐EM Structure Guided Engineering of Botulinum Neurotoxin A With Advanced Receptor Binding Affinity and Therapeutical Benefits

Advanced Science, EarlyView.
The butterfly unfolded wing in an open form structure of botulinum neurotoxin type A (BoNT/A) at physiological‐state was confirmed at 2.85 Å resolution by cryo‐electron microscopy (cryo‐EM). Structure‐guided protein engineering significantly enhanced the receptor‐binding affinity, therapeutic efficacy, and safety of the engineered toxin variants ...
Wenrui Wang, Zhaxi Zerang, Linjin You, Ziye Liu, Rong Nie, Fuwei Qi, Fenfen Gao, Chengmu Zhao, Wantong Ma, Jinghan He, Xiaoru Wang, Shanquan Wu, Bo Liu, Xinyao Liu, Dongsheng Lei, Dejuan Zhi, Dongsheng Wang   +16 more
wiley   +1 more source

Proinflammatory cytokines modify Ca²⁺ signaling and induce an apoptotic lipidome in murine small intestinal organoids. [PDF]

Front Physiol
Pauer SM, Schindler A, Ghezellou P, Spengler B, Diener M, Ballout J.   +5 more
europepmc   +1 more source

SKOOTS: Skeleton‐Oriented Object Segmentation for Mitochondria in High‐Resolution Cochlear EM Datasets

Advanced Science, EarlyView.
Skeleton‐oriented object segmentation (SKOOTS) introduces a new strategy for 3D mitochondrial instance segmentation by predicting explicit skeletons rather than relying on boundary cues. This approach enables robust analysis of densely packed organelles in large FIB‐SEM datasets.
Christopher J. Buswinka, Richard T. Osgood, Hidetomi Nitta, Artur A. Indzhykulian   +3 more
wiley   +1 more source

Systems Forces Leading to Feeding Tube Placement in Patients with Advanced Dementia: A Qualitative Exploration of Clinical Momentum. [PDF]

J Palliat Med
Zaza SI, Jacobson N, Buffington A, Dudek A, Haug K, Bradley T, Bushaw KJ, Kalbfell EL, Kwekkeboom K, Schwarze ML.   +9 more
europepmc   +1 more source

Delivery of Pleckstrin‐Homology Domains Suppresses PI3K/Akt Signaling and Breast Cancer Metastasis

Advanced Science, EarlyView.
Current therapies curb tumor growth but not metastasis. Obscurin, a giant metastasis suppressor lost in breast cancer, restrains PI3K/Akt signaling but is impractical to restore. We deploy a mini‐obscurin, comprising the obscurin‐PH‐domain, which sequesters PI3K‐p85, potently suppressing invasion and metastasis.
Matthew Eason, Anindya Sen, Suhan Cho, Se Jong Lee, Keyata Thompson, Md Musavvir Mahmud, Poornima Dubey, Talia Guardia, Anthony Kim, Stuart Martin, Nathan Wright, Konstantinos Konstantopoulos, Aikaterini Kontrogianni‐Konstantopoulos   +12 more
wiley   +1 more source

Building-integrated solar water disinfection system for reliable year-round drinking water safety. [PDF]

NPJ Clean Water
Pretorius M, Jeon I, Martínez-Fausto MM, Novelli N, Arevalo JLG, Ryberg E, Derby MM, Kim JH, Dyson A.   +8 more
europepmc   +1 more source

The Transcription Factor FgSge1 Harnesses the SAGA Complex to Activate Mycotoxin Biosynthesis and Fungal Virulence

Advanced Science, EarlyView.
This study reveals the molecular mechanism by which the transcription factor FgSge1 regulates mycotoxin biosynthesis and virulence in Fusarium graminearum. FgSge1 binds to the TAARGTTT cis‐element, enabling self‐activation. It recruits the SAGA complex, promotes histone acetylation, and facilitates jet‐like chromatin remodeling, thereby activating ...
Yueqi Zhang, Jingrui Wang, Qiaowan Chen, Chen Jiao, Yun Chen, Zhongshou Wu, Zhonghua Ma   +6 more
wiley   +1 more source

Unconscious death thoughts: Do they play a role in time trade-off and visual analogue scale scores for health? [PDF]

Qual Life Res
Stalmeier P, Rencz F, Rutjens B, Roudijk B.   +3 more
europepmc   +1 more source

Standardization Improves Discharge Care Coordination for Children with Nasogastric Tubes. [PDF]

Pediatr Qual Saf
Rickey LM, Nagle K, Perkins J, Kohler C, Ethier B, Fontaine K, Matherson S, Stack AM, McSweeney ME.   +8 more
europepmc   +1 more source