Results 191 to 200 of about 1,932,119 (245)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

A Multidimensional Framework for Pharmaceutical Care to Enhance Medication Adherence and Patient Engagement: The CMO-MAPEX Model. [PDF]

Patient Prefer Adherence
Morillo-Verdugo R, Ibarra-Barrueta O, Martin Conde MT, Vicente-Escrig E, Contreras Macias E.   +4 more
europepmc   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

A new framework to consider equity in urban intervention planning, implementation and evaluation: development and application in a case study on an urban play spaces policy. [PDF]

BMC Public Health
Ahrens J, White M, Jeram S, Ristovska G, Koning J, Gudi-Mindermann H, Tönnies J, Czwikla G, Weber M, Bolte G.   +9 more
europepmc   +1 more source

Balancing the extremes for antibody developability: hydrophobic and electrostatic germline framework signatures for CDR-loop compensation. [PDF]

MAbs
Spanke VA, Egger-Hoerschinger VJ, Seidler CA, Kroell KB, Wieser V, Imhof-Jung S, Weiche B, Bujotzek A, Georges G, Liedl KR.   +9 more
europepmc   +1 more source

A conceptual health economic modelling framework to assess the cost-effectiveness of molecular target-driven treatment regimens in oncology. [PDF]

Acta Oncol
Frisell O, Aas E, Henkel PS, Fagereng GL, Taskén K, Hallersjö Hult E, Lindgren P, Steen Carlsson K.   +7 more
europepmc   +1 more source

Selective detection of arsenite in alkaline media using a yolk-shell (Ce/Fe) terephthalate/organoclay framework stripping voltammetric sensor. [PDF]

Mikrochim Acta
Elfiky M, Beltagi AM.
europepmc   +1 more source

Ensuring Reliability of Curated Electronic Health Record-Derived Data: The Validation of Accuracy for Large Language Model-/Machine Learning-Extracted Information and Data (VALID) Framework. [PDF]

JCO Clin Cancer Inform
Estevez M, Singh N, Dyson L, Adamson B, Krismer K, Magee K, Yuan Q, Hildner MW, Fidyk E, Williams T, Mbah O, Khan F, Seidl-Rathkopf K, Cohen AB.   +13 more
europepmc   +1 more source