Results 221 to 230 of about 15,676,085 (372)

On Framework

Film-Philosophy, 2001
openaire   +2 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

The POETIC (PrOcess Evaluation of Trials In Critical care) Framework: A Structured Approach for Designing and Conducting Process Evaluations in Critical Care Trials. [PDF]

Crit Care Explor
Emerson LM, McAuley DF, Blackwood B, Clarke M.   +3 more
europepmc   +1 more source

Draft area inspection framework for consultation: a supplement to the Common inspection framework [PDF]

, 2003

core  

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Utjecaj Okvirne konvencije za zaštitu nacionalnih manjina na razvoj ostvarivanja prava nacionalnih manjina: trinaest godina nakon stupanja na snagu

Migracijske i etničke teme, 2011
Milena Klajner
doaj  

Developing a Gender Framework for Responsive and Adaptive Design in Digital Health (FORWARD) from a review of reviews. [PDF]

BMC Digit Health
Kalbarczyk A, Saksena K, Carras MC, Gomes I, Zon J, Zhou X, Agarwal S.   +6 more
europepmc   +1 more source

Metal organic frameworks as a drug delivery system for flurbiprofen

, 2017
Muder Al Hayder, Hussein Rasool Abid, Bruce Sunderland, Shaobin Wang   +3 more
openalex   +2 more sources

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

A competency-based leadership framework for public health trainers in Meghalaya: insights from a multi-method study. [PDF]

BMJ Public Health
Bumb D, Gupta P, Nooyi SC, Chaudhury N.
europepmc   +1 more source