Results 221 to 230 of about 5,283,663 (317)

TransNet-SAM2: A Transformer-Foundation Model Framework for Prompt-Free Segmentation of White Blood Cells in Microscopic Blood Smear Images. [PDF]

Diagnostics (Basel)
Bamwenda J, Özerdem MS, Ayyildiz O, Akpolat V, Akpolat İ.   +4 more
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

A Large Language Model-Powered Multiagent Framework Emulating Standardized Patients in Clinical Communication Skills Training: Development and Evaluation Study. [PDF]

J Med Internet Res
Qu Y, Xu X, Long Y, Wang Y, Li J, Lu X.
europepmc   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

A Patient Bill of Rights and Responsibilities for Wound Prevention and Care in Canada: Grounded in Stories and Guided by Co-Design and Community-Based Participatory Principles. [PDF]

Int Wound J
Costa IG, Philips C, Stevens K, Schoales C, Bajnok I, Botros M, Strachan R, Santorelli S, Camargo-Plazas P.   +8 more
europepmc   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

AI-assisted thematic synthesis of existing neurological core outcome sets: A descriptive reference framework (COS-Neuro). [PDF]

PLoS One
Tiong SP, Yang X, Touzet AY, Millward CP, Zipser CM, Tetreault L, Gharooni A, Davies BM.   +7 more
europepmc   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Reconstructing the Post-Burn Auricle: A Microsurgical Approach Using a Contralateral Free Temporoparietal Fascial Flap and Autologous Costal Cartilage Framework. [PDF]

Clin Case Rep
Wei S, Chen Y, Dong L.
europepmc   +1 more source