Results 251 to 260 of about 5,283,663 (317)
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Frameworks to Evaluate the Quality of Public Involvement in Health and Social Care Research: A Scoping Review. [PDF]
Health ExpectHutton R +5 more
europepmc +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
A two stage statistical framework for cold start spare part demand forecasting. [PDF]
PLoS OneB SN +5 more
europepmc +1 more source
A structured and embodied framework (SAEF) for pain communication and externalization. [PDF]
MethodsXM AA, Karthiga RKJ.
europepmc +1 more source
A hybrid BiLSTM-transformer-GCN architecture with API fusion for adaptive transportation resource analytics. [PDF]
PLoS OneJaveed MS +4 more
europepmc +1 more source
Correction for Zhang et al., Deep learning framework for quantifying self-organization in <i>Myxococcus xanthus</i>. [PDF]
Proc Natl Acad Sci U S Aeuropepmc +1 more source