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Managing contract manufacturing relationships : an explorative research framework
, 2021 Purpose: Contract manufacturing has established itself as a cornerstone of manufacturing practices across industries. The high degree of external value creation, operational interfaces, relational dynamics, and knowledge exchange coordination require demand-oriented management of contract manufacturing service providers from an outsourcing company's ...
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Slither: A Static Analysis Framework for Smart Contracts [PDF]
2019 IEEE/ACM 2nd International Workshop on Emerging Trends in Software Engineering for Blockchain (WETSEB), 2019 This paper describes Slither, a static analysis framework designed to provide rich information about Ethereum smart contracts. It works by converting Solidity smart contracts into an intermediate representation called SlithIR. SlithIR uses Static Single Assignment (SSA) form and a reduced instruction set to ease implementation of analyses while ...
Feist, Josselin +2 more
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Continuous and Secure Integration Framework for Smart Contracts
Sensors, 2023 As part of agile methodologies seen in the past few years, IT organizations have continuously adopted new practices in their software delivery life-cycle to improve both efficiency and effectiveness of development teams. Two of these practices are continuous integration and continuous deployment, which are part of the DevOps cycle which has helped ...
Alvaro Reyes +2 more
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Molecular Oncology, EarlyView.A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira +14 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Validation Framework for E-Contract and Smart Contract
We propose and develop a framework for validating smart contracts derived from e-contracts. The goal is to ensure the generated smart contracts fulfil all the conditions outlined in their corresponding e-contracts. By confirming alignment between the smart contracts and their original agreements, this approach enhances trust and reliability in ...
Godboley, Sangharatna +3 more
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A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy
Molecular Oncology, EarlyView.Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti +3 more
wiley +1 more source
Preliminary Results Towards Contract Monitorability [PDF]
Electronic Proceedings in Theoretical Computer Science, 2016 This paper discusses preliminary investigations on the monitorability of contracts for web service descriptions. There are settings where servers do not guarantee statically whether they satisfy some specified contract, which forces the client (i.e., the
Annalizz Vella, Adrian Francalanza
doaj +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source