Results 231 to 240 of about 1,162,932 (298)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Mapping intersectionality in dementia care research: a decadal scoping review. [PDF]

Front Dement
Roes M, Laporte Uribe F, Felding SA, Charlesworth G, Müller N, Berdai S, Bhatt J, Altinok K, Peters-Nehrenheim V.   +8 more
europepmc   +1 more source

From Bench to Bedside: Evolving Definitions of Translational Research. [PDF]

Saudi Med J
Alhumud HA, Alanazi FK, DeVol EB.
europepmc   +1 more source

Embedding Research in Clinical Practice: The Integrated Research Enablement Framework (IREF). [PDF]

Aust J Rural Health
Flenady T.
europepmc   +1 more source

Integrating ESG indicators into public health governance as a policy innovation for institutional accountability: a scoping review. [PDF]

Public Health Rev
Catalfo P, Virgillito D, Messina G, Ledda C.   +3 more
europepmc   +1 more source