Results 31 to 40 of about 3,621,181 (303)
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Construction planning workbench [PDF]
, 2004 This report is an attempt to present the current state of product and process modelling in the building industry in general, and in construction planning and scheduling in particular.
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Signum: Estudos da Linguagem, 2019 The objective of this article is to analyze the construction of the referent “vehicle” in advertisements, proposing an interface between Referencing and Multimodality.
Luciene Helena da Silva +1 more
doaj +1 more source
Fusion frame constructions and frame partitions [PDF]
, 2018 Fusion frames consist of a sequence of subspaces from a Hilbert space and corresponding positive weights so that the sum of weighted orthogonal projections onto these subspaces is an invertible operator on the space. Despite extensive literature on fusion frames, and several construction methods for unit-weight fusion frames with prescribed subspace ...
openaire +2 more sources
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
Modelling construction business performance [PDF]
, 2008 Searching academic databases for records on ‘business failure’, ‘business distress’ or ‘bankruptcy’\ud yields a large body of studies on qualitative, empirical, theoretical and simulation aspects.
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Australian college punters in the United States: a framing & cultivation analysis
, 2023 Brewer, Paul R.This dissertation sought to examine audience framing related to Australian college punters in the U.S., the effects that various forms of sports media have on attitudes toward these athletes, and the extent to which textual and visual ...
Bingaman, James
core +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Adoption in the construction industry [PDF]
, 2006 This report draws together the key findings from six case studies on the subject of ebusiness\ud Adoption in Construction conducted in Australia by the University of Newcastle\ud (UON) and Royal Melbourne Institute of Technology (RMIT) from 2005 through ...
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