Results 61 to 70 of about 441,728 (330)
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Resounding News: The Acoustic Conventions of Israeli Newscasts
International Journal of Communication, 2017 This article takes sound as its analytical point of departure in asking the following question: What does sound do in television news? Exploring the conventions of sound used by producers of Israeli television news, from the signature tune to the ...
Hadar Levy, Amit Pinchevski
doaj +2 more sources
The classification of certain linked $3$-manifolds in $6$-space [PDF]
, 2015 We work entirely in the smooth category. An embedding $f:(S^2\times S^1)\sqcup S^3\rightarrow {\mathbb R}^6$ is {\it Brunnian}, if the restriction of $f$ to each component is isotopic to the standard embedding.
Avvakumov, Sergey
core +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
M-Theory with Framed Corners and Tertiary Index Invariants [PDF]
, 2014 The study of the partition function in M-theory involves the use of index theory on a twelve-dimensional bounding manifold. In eleven dimensions, viewed as a boundary, this is given by secondary index invariants such as the Atiyah-Patodi-Singer eta ...
Sati, Hisham
core +3 more sources
Review on Cold-Formed Steel Connections
The Scientific World Journal, 2014 The concept of cold-formed light steel framing construction has been widespread after understanding its structural characteristics with massive research works over the years.
Yeong Huei Lee +4 more
doaj +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
The 1985 Chile earthquake: Structural characteristics and damage statistics for the building inventory in Vina del Mar [PDF]
, 1987 The Chile earthquake of 3 March 1985 resulted in an effective peak acceleration of 0.36g in the coastal city of Vina del Mar. The city had an inventory of over 400 reinforced concrete buildings ranging in height from 5 to 23 stories.
de la Llera, J.C. +2 more
core
Construction of Compactly Supported Shearlet Frames [PDF]
Constructive Approximation, 2011 Shearlet tight frames have been extensively studied during the last years due to their optimal approximation properties of cartoon-like images and their unified treatment of the continuum and digital setting. However, these studies only concerned shearlet tight frames generated by a band-limited shearlet, whereas for practical purposes compact support ...
Kittipoom, Pisamai +2 more
openaire +3 more sources