Results 1 to 10 of about 972,269 (340)

Digital Connectedness in the Framingham Heart Study [PDF]

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
BackgroundNew avenues of data collection such as eHealth and mobile technology have the potential to revolutionize the way large populations can be assessed and managed outside of standard research and clinical settings.
Caroline S. Fox, Shih‐Jen Hwang, Kenneth Nieto, Maureen Valentino, Karen Mutalik, Joseph M. Massaro, Emelia J. Benjamin, Joanne M. Murabito   +7 more
doaj   +5 more sources

Expression quantitative trait methylation analysis elucidates gene regulatory effects of DNA methylation: the Framingham Heart Study [PDF]

Scientific Reports, 2023
Expression quantitative trait methylation (eQTM) analysis identifies DNA CpG sites at which methylation is associated with gene expression. The present study describes an eQTM resource of CpG-transcript pairs derived from whole blood DNA methylation and ...
Amena Keshawarz, Helena Bui, Roby Joehanes, Jiantao Ma, Chunyu Liu, Tianxiao Huan, Shih-Jen Hwang, Brandon Tejada, Meera Sooda, Paul Courchesne, Peter J. Munson, Cumhur Y. Demirkale, Chen Yao, Nancy L. Heard-Costa, Achilleas N. Pitsillides, Honghuang Lin, Ching-Ti Liu, Yuxuan Wang, Gina M. Peloso, Jessica Lundin, Jeffrey Haessler, Zhaohui Du, Michael Cho, Craig P. Hersh, Peter Castaldi, Laura M. Raffield, Jia Wen, Yun Li, Alexander P. Reiner, Mike Feolo, Nataliya Sharopova, Ramachandran S. Vasan, Dawn L. DeMeo, April P. Carson, Charles Kooperberg, Daniel Levy   +35 more
doaj   +2 more sources

Copy number variation in the Framingham Heart Study [PDF]

BMC Proceedings, 2009
Abstract In this paper we test for association between copy number variation and diabetes in a subset of individuals from the Framingham Heart Study. We used the 500 k SNP data and called copy number variation using two algorithms: the genome alteration detection algorithm of Pique-Regi et al. and the software Golden Helix. We then tested for
Corina Shtir, Roger Piqué-Regi, Kim Siegmund, John L. Morrison, Fredrick R. Schumacher, Paul Marjoram   +5 more
openalex   +3 more sources

Cognitive Performance after Stroke – The Framingham Heart Study [PDF]

International Journal of Stroke, 2014
Background Individuals with a high risk of stroke are also more prone to cognitive impairment perhaps because of concomitant vascular risk factors. In addition, clinical stroke increases the risk of subsequent dementia. Nevertheless, the relationship between clinical stroke and subsequent cognitive function in initially nondemented individuals remains ...
Galit Weinstein, Sarah R. Preis, Alexa Beiser, Rhoda Au, Margaret Kelly‐Hayes, Carlos S. Kase, Philip A. Wolf, Sudha Seshadri   +7 more
openalex   +3 more sources

The epidemiology of heart failure: The Framingham Study [PDF]

Journal of the American College of Cardiology, 1993
Congestive heart failure has become an increasingly frequent reason for hospital admission during the last 2 decades and clearly represents a major health problem.
Ho, Kalon K.L., Pinsky, Joan L., Kannel, William B., Levy, Daniel   +3 more
core   +6 more sources

Genome-wide association study of electrocardiographic and heart rate variability traits: the Framingham Heart Study [PDF]

, 2007
BACKGROUND: Heritable electrocardiographic (ECG) and heart rate variability (HRV) measures, reflecting pacemaking, conduction, repolarization and autonomic function in the heart have been associated with risks for cardiac arrhythmias.
Guo, Chao-Yu, Larson, Martin G., Levy, Daniel, Newton-Cheh, Christopher, O'Donnell, Christopher J., Wang, Thomas J.   +5 more
core   +31 more sources

Identifying Blood Biomarkers for Dementia Using Machine Learning Methods in the Framingham Heart Study

Cells, 2022
Blood biomarkers for dementia have the potential to identify preclinical disease and improve participant selection for clinical trials. Machine learning is an efficient analytical strategy to simultaneously identify multiple candidate biomarkers for ...
Honghuang Lin, Jayandra J. Himali, Claudia L. Satizabal, Alexa S. Beiser, Daniel Levy, Emelia J. Benjamin, Mitzi M. Gonzales, Saptaparni Ghosh, Ramachandran S. Vasan, Sudha Seshadri, Emer R. McGrath   +10 more
doaj   +1 more source

Growth Differentiation Factor 15 and NT‐proBNP as Blood‐Based Markers of Vascular Brain Injury and Dementia

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background GDF15 (growth differentiation factor 15) and NT‐proBNP (N‐terminal pro‐B‐type natriuretic peptide) may offer promise as biomarkers for cognitive outcomes, including dementia.
Emer R. McGrath, Jayandra J. Himali, Daniel Levy, Sarah C. Conner, Charles DeCarli, Matthew P. Pase, Toshiharu Ninomiya, Tomoyuki Ohara, Paul Courchesne, Claudia L. Satizabal, Ramachandran S. Vasan, Alexa S. Beiser, Sudha Seshadri   +12 more
doaj   +1 more source

Epigenome-wide association study of DNA methylation and microRNA expression highlights novel pathways for human complex traits

Epigenetics, 2020
DNA methylation (DNAm) and microRNAs (miRNAs) have been implicated in a wide-range of human diseases. While often studied in isolation, DNAm and miRNAs are not independent. We analyzed associations of expression of 283 miRNAs with DNAm at >400K CpG sites
Tianxiao Huan, Michael Mendelson, Roby Joehanes, Chen Yao, Chunyu Liu, Ci Song, Anindya Bhattacharya, Jian Rong, Kahraman Tanriverdi, Joshua Keefe, Joanne M. Murabito, Paul Courchesne, Martin G. Larson, Jane E. Freedman, Daniel Levy   +14 more
doaj   +1 more source

Neck Circumference and Risk of Incident Atrial Fibrillation in the Framingham Heart Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022
Background Increased neck circumference, a proxy for upper‐body subcutaneous fat, is associated with cardiovascular risk and metabolic risk factors, accounting for body mass index (BMI) and waist circumference.
Jelena Kornej, Honghuang Lin, Ludovic Trinquart, Corban R. Jackson, Darae Ko, Emelia J. Benjamin, Sarah R. Preis   +6 more
doaj   +1 more source