Results 101 to 110 of about 972,269 (340)

A fast algorithm for detecting gene-gene interactions in genome-wide association studies [PDF]

, 2014
With the recent advent of high-throughput genotyping techniques, genetic data for genome-wide association studies (GWAS) have become increasingly available, which entails the development of efficient and effective statistical approaches.
Li, Jiahan, Li, Runze, Wu, Rongling, Zhong, Wei   +3 more
core   +1 more source

Metformin attenuates metabolic insulin sensitivity and insulin‐stimulated carbohydrate oxidation after high‐intensity exercise training in adults at risk for metabolic syndrome

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aims Mixed evidence exists on whether metformin adds to or attenuates the insulin‐sensitising effects of exercise. To date, no studies have tested whether metformin differentially impacts exercise training intensity–mediated insulin sensitivity.
Steven K. Malin, Emily M. Heiston, Daniel J. Battillo, Tristan J. Ragland, Anna Ballantyne, Sue A. Shapses, Ankit M. Shah, James T. Patrie   +7 more
wiley   +1 more source

Trajectories of Blood Lipid Concentrations Over the Adult Life Course and Risk of Cardiovascular Disease and All‐Cause Mortality: Observations From the Framingham Study Over 35 Years

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background Elevated total cholesterol (TC), low‐density lipoprotein cholesterol (LDL‐C), triglycerides, and non‐high‐density lipoprotein cholesterol (non‐HDL‐C) and low high‐density lipoprotein cholesterol (HDL‐C) concentrations correlate with ...
Meredith S. Duncan, Ramachandran S. Vasan, Vanessa Xanthakis   +2 more
doaj   +1 more source

Understanding Atrial Fibrillation Complexity Through the Lens of Turbulence Dynamics: Implications for Treatment Strategies

Journal of Cardiovascular Electrophysiology, EarlyView.
ABSTRACT Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia encountered in clinical practice. Its incidence increases significantly with age and has become a major global public health issue. Although research into the mechanisms of AF has spanned over a century‐ranging from the reentry theory to the rotor hypothesis‐none of these
Xin Chu, Xiaohan Jiang, Qing Qiao, Xiaojun Wang, Hong Ye   +4 more
wiley   +1 more source

Cruciferous vegetable intake and cardiovascular disease risk in the Framingham Offspring Cohort [PDF]

, 2019
Fruit and vegetable intake has been demonstrated to be inversely correlated with CVD risk, but it remains to be elucidated whether different subclasses of fruits and vegetables and their bioactive constituents have different effects on CVD risk ...
Sager, Jenna
core  

Trends in excess mortality associated with atrial fibrillation over 45 years (Framingham Heart Study): community based cohort study

British medical journal, 2020
Objective To assess temporal trends in the association between newly diagnosed atrial fibrillation and death. Design Community based cohort study. Setting Framingham Heart Study cohort, in 1972-85, 1986-2000, and 2001-15 (periods 1-3, respectively), in ...
Nicklas Vinter, Qiuxi Huang, M. Fenger-Grøn, L. Frost, E. Benjamin, L. Trinquart   +5 more
semanticscholar   +1 more source

Non-valvular atrial fibrillation and stroke : implications for management [PDF]

, 1995
Nonvalvular Atrial Fibrillation is more prevalent with increasing age. It is associated with a six-fold excess risk of stroke; and a cumulative lifetime stroke risk of 35%. 15% of ischaemic strokes are directly attributable to it.
Tilney, Myra Kay
core  

The “Reducing Inflammation for Greater Health Trial (RIGHT)” Study—Concept, Rationale, and Design

Journal of the American Geriatrics Society, EarlyView.
ABSTRACT The Reducing Inflammation for Greater Health Trial's (RIGHT) study is a single‐center, randomized, double‐blind, placebo‐controlled trial designed to test whether clazkizumab, an interleukin‐6 (IL‐6) inhibitor, can improve or slow decline in physical, cognitive, and vascular function in older adults, when compared to a placebo.
Sebastian E. Sattui, Marnie Bertolet, Daniel E. Forman, Michelle E. Danielson, Shanshan Yao, Oscar L. Lopez, Nancy W. Glynn, Neelesh K. Nadkarni, Akira Sekikawa, Tullia C. Bruno, Toren Finkel, Anne B. Newman   +11 more
wiley   +1 more source

Incidence of Hip Fracture Over 4 Decades in the Framingham Heart Study.

JAMA Internal Medicine, 2020
Importance Age-adjusted hip fracture incidence is decreasing in the US. The decrease has been attributed to osteoporosis treatment, but the cause is unknown. Objective To examine the decrease in hip fracture incidence over the past 40 years in the US.
Jay Swayambunathan, A. Dasgupta, P. Rosenberg, M. Hannan, D. Kiel, T. Bhattacharyya   +5 more
semanticscholar   +1 more source

Genome-wide identification of DNA methylation QTLs in whole blood highlights pathways for cardiovascular disease

Nature Communications, 2019
Differentially methylated CpGs can inform on disease mechanisms and be useful as biomarkers. Here, the authors perform GWAS for DNA methylation in whole blood, cis- and trans-meQTL mapping, followed by Mendelian randomization analysis that links meQTLs ...
Tianxiao Huan, Roby Joehanes, Ci Song, Fen Peng, Yichen Guo, Michael Mendelson, Chen Yao, Chunyu Liu, Jiantao Ma, Melissa Richard, Golareh Agha, Weihua Guan, Lynn M. Almli, Karen N. Conneely, Joshua Keefe, Shih-Jen Hwang, Andrew D. Johnson, Myriam Fornage, Liming Liang, Daniel Levy   +19 more
doaj   +1 more source