Results 111 to 120 of about 972,269 (340)

Whole blood gene expression and white matter Hyperintensities

Molecular Neurodegeneration, 2017
Background White matter hyperintensities (WMH) are an important biomarker of cumulative vascular brain injury and have been associated with cognitive decline and an increased risk of dementia, stroke, depression, and gait impairments. The pathogenesis of
Honghuang Lin, Claudia Satizabal, Zhijun Xie, Qiong Yang, Tianxiao Huan, Roby Joehanes, Chengping Wen, Peter J. Munson, Alexa Beiser, Daniel Levy, Sudha Seshadri   +10 more
doaj   +1 more source

The Swedish CArdioPulmonary bioImage Study re‐examination: Rationale, design, methods, and management of incidental findings

Journal of Internal Medicine, EarlyView.
Abstract Objectives To describe the rationale, design and data collection procedures of the Swedish CArdioPulmonary bioImage Study (SCAPIS) re‐examination, which, in its further scope, aims to quantify and explain the development of atherosclerosis, pathological cardiovascular ageing, longitudinal decline in lung function and the malignant ...
Elin Good, Göran Bergström, Anders Blomberg, Viiu Blöndal, Gunnar Engström, Erika Fagman, Klas Gränsbo, Shabab Hasan, Shadi Jalali, Tomas Jernberg, Åse Johnsson, Ioannis Katsoularis, Jeanette Kuhl, Andrei Malinovschi, Lina Malm, Vibeke Sparring, Eva Swahn, Richard Ssegonja, Jelmer Westra, Mischa Woisetschläger, Carl Johan Östgren, Emil Hagström   +21 more
wiley   +1 more source

Cross‐Sectional Associations of Computed Tomography (CT)‐Derived Adipose Tissue Density and Adipokines: The Framingham Heart Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
BackgroundExcess accumulation of abdominal subcutaneous (SAT) and visceral adipose tissue (VAT) is associated with adverse levels of adipokines and cardiovascular disease risk.
Jane J. Lee, Alison Pedley, Udo Hoffmann, Joseph M. Massaro, John F. Keaney, Ramachandran S. Vasan, Caroline S. Fox   +6 more
doaj   +1 more source

Coronary age, based on coronary calcium measurement, is increased in patients with morbid obesity [PDF]

, 2018
Purpose: Obesity is a well-known of risk factor for atherosclerosis. However, recently an "obesity paradox" has been discussed, which is considered as a protective effect of obesity on the development coronary artery disease (CAD).
Białecki, Marcin, Hawrył, Mateusz, Lemanowicz, Adam, Leszczyński, Waldemar   +3 more
core   +1 more source

Impact of Electronic Nicotine Delivery Systems on Oral Mucosa: A Cytopathological and Molecular Study

Journal of Oral Pathology &Medicine, EarlyView.
ABSTRACT Background The packaging and marketing of electronic cigarettes (e‐cigs) often target younger demographics. This study aimed to evaluate gene expression in e‐cig users through exfoliative cytology. Methods Samples were collected from 17 e‐cig users and 10 nonsmokers as controls.
Alba Pérez‐Jardón, Bruna Fernandes do Carmo Carvalho, Cintia Micaela Chamorro‐Petronacci, Maria Dolores Reboiras‐López, Natalia de Carvalho Faria, Renata Falchete do Prado, Mónica Ghislaine Oliveira Alves, Fábio França Vieira e Silva, Maria‐Elena Padín‐Iruegas, Mario Pérez‐Sayáns, Janete Dias Almeida   +10 more
wiley   +1 more source

Association of Variability in Body Mass Index and Metabolic Health With Cardiometabolic Disease Risk

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background Metabolic syndrome is associated with high risk of cardiovascular disease, although risk may differ according to the specific conditions present and variability in those conditions. Methods and Results We defined obesity (body mass index [BMI]
Todd R. Sponholtz, Edwin R. van den Heuvel, Vanessa Xanthakis, Ramachandran S. Vasan   +3 more
doaj   +1 more source

Lifetime Risk of Lower-Extremity Peripheral Artery Disease Defined by Ankle-Brachial Index in the United States. [PDF]

, 2019
Background There are no available lifetime risk estimates of lower-extremity peripheral artery disease (PAD). Methods and Results Using data from 6 US community-based cohorts and the vital statistics, we estimated the prevalence and incidence of PAD ...
Allison, Matthew, Ballew, Shoshana H, Chow, Eric K, Coresh, Josef, Criqui, Michael, Grams, Morgan E, Lloyd-Jones, Donald M, Matsushita, Kunihiro, Ning, Hongyan, Sang, Yingying, Selvin, Elizabeth, Wilkins, John T   +11 more
core   +1 more source

Causal relevance of blood lipid fractions in the development of carotid atherosclerosis: Mendelian randomization analysis. [PDF]

, 2013
BACKGROUND: Carotid intima-media thickness (CIMT), a subclinical measure of atherosclerosis, is associated with risk of coronary heart disease events. Statins reduce progression of CIMT and coronary heart disease risk in proportion to the reduction in ...
Baldassarre, Damiano, Casas, Juan-Pablo, de Faire, Ulf, Deanfield, John, Drenos, Fotios, Gertow, Karl, Gigante, Bruna, Hamsten, Anders, Hingorani, Aroon D, Holmes, Michael V, Humphries, Steve E, Kivimaki, Mika, Kumari, Meena, Langenberg, Claudia, Sennblad, Bengt, Shah, Sonia, Strawbridge, Rona J, Swerdlow, Daniel I, Talmud, Philippa J, Tremoli, Elena, Veglia, Fabrizio, Wareham, Nick, Whittaker, John   +22 more
core   +1 more source

Severe Periodontitis is Associated With Recurrent Cardiovascular Events—A 10‐Year Longitudinal Cohort Study

Journal of Periodontal Research, EarlyView.
One thousand and two patients with cardiovascular disease (CVD) were observed over 10 years. Data were collected from 792 study participants. Severe periodontitis proved to be an independent risk factor for new cardiovascular events. Tooth brushing more than once a day and performing interdental hygiene were associated with decreased risk.
Stefan Reichert, Selina Rehm, Axel Schlitt, Susanne Schulz   +3 more
wiley   +1 more source

The genetics of platelet count and volume in humans

Platelets, 2018
The last decade has witnessed an explosion in the depth, variety, and amount of human genetic data that can be generated. This revolution in technical and analytical capacities has enabled the genetic investigation of human traits and disease in ...
John D. Eicher, Guillaume Lettre, Andrew D. Johnson   +2 more
doaj   +1 more source