Results 121 to 130 of about 954,985 (333)

Hematocrit and left ventricular mass: the Framingham Heart study

Journal of the American College of Cardiology, 2004
The goal of this study was to investigate the relationship between hematocrit (Hct) and left ventricular mass index (LVMI) and LV hypertrophy (LVH) in subjects without known hypertension or cardiovascular disease in the Framingham Heart study.Anemia may be an independent risk factor for cardiovascular disease in the general population.
Deeb N. Salem, Hocine Tighiouart, Paul Stark, Bonnie MacLeod, John L. Griffith, Mark J. Sarnak, Daniel E. Weiner, Manish G. Amin   +7 more
openaire   +3 more sources

Association of Epigenetic Age Acceleration and Mitochondrial DNA‐Based Aging Metrics Provides Insights Into Mechanisms of Aging‐Related Diseases

Aging Cell, EarlyView.
Older participants exhibit lower mtDNA copy number (CN) and a higher rare heteroplasmy burden, while common heteroplasmy burden remains relatively stable. Higher epigenetic age acceleration is associated with lower mtDNA CN and higher rare heteroplasmy burden in 6316 participants.
Mengyao Wang, Yinan Zheng, Meng Lai, Emmanuel Saake, Xue Liu, Xiuqing Guo, Kent D. Taylor, Tianxiao Huan, Roby Joehanes, Drew R. Nannini, Kai Zhang, Nicole J. Lake, Christina A. Castellani, Stephen S. Rich, Jerome I. Rotter, Yongmei Liu, Laura M. Raffield, April P. Carson, Myriam Fornage, Jiantao Ma, Dan E. Arking, Lifang Hou, Daniel Levy, Chunyu Liu   +23 more
wiley   +1 more source

Whole blood gene expression and white matter Hyperintensities

Molecular Neurodegeneration, 2017
Background White matter hyperintensities (WMH) are an important biomarker of cumulative vascular brain injury and have been associated with cognitive decline and an increased risk of dementia, stroke, depression, and gait impairments. The pathogenesis of
Honghuang Lin, Claudia Satizabal, Zhijun Xie, Qiong Yang, Tianxiao Huan, Roby Joehanes, Chengping Wen, Peter J. Munson, Alexa Beiser, Daniel Levy, Sudha Seshadri   +10 more
doaj   +1 more source

Evidence of widespread selection on standing variation in Europe at height-associated SNPs. [PDF]

, 2012
Strong signatures of positive selection at newly arising genetic variants are well documented in humans(1-8), but this form of selection may not be widespread in recent human evolution(9).
Chiang, Charleston WK, Genetic Investigation of ANthropometric Traits (GIANT) Consortium, Hirschhorn, Joel N, Palmer, Cameron D, Reich, David, Sankararaman, Sriram, Turchin, Michael C   +6 more
core   +1 more source

Cardiovascular Health in Women—Across the Lifespan

Clinical Endocrinology, EarlyView.
ABSTRACT Cardiovascular disease (CVD) remains the leading cause of mortality and morbidity among women worldwide. However, CVD continues to be perceived as a predominantly male issue. CVD in women therefore remains understudied, underrecognized and undertreated.
Jaya Chandrasekhar, Jessica Yao, Simone Gong, Madhuka Wijayarathne, Monique Watts, Swati Mukherjee   +5 more
wiley   +1 more source

Relations Between Aortic Stiffness and Left Ventricular Mechanical Function in the Community

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundAortic stiffness impairs optimal ventricular–vascular coupling and left ventricular systolic function, particularly in the long axis. Left ventricular global longitudinal strain (GLS) has recently emerged as a sensitive measure of early cardiac
Vanessa Bell, Elizabeth L. McCabe, Martin G. Larson, Jian Rong, Allison A. Merz, Ewa Osypiuk, Birgitta T. Lehman, Plamen Stantchev, Jayashri Aragam, Emelia J. Benjamin, Naomi M. Hamburg, Ramachandran S. Vasan, Gary F. Mitchell, Susan Cheng   +13 more
doaj   +1 more source

Tirzepatide and the 10‐year predicted risk of cardiovascular disease and type 2 diabetes in adults with obesity and prediabetes: A post hoc analysis from the three‐year SURMOUNT‐1 trial

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aim We assessed the association between tirzepatide and the 10‐year predicted risk of developing cardiovascular disease (CVD) and type 2 diabetes (T2D) among three‐year SURMOUNT‐1 trial participants. Materials and Methods This post hoc analysis applied validated risk engines that predict 10‐year CVD (atherosclerotic cardiovascular disease ...
Emily R. Hankosky, Jeremie Lebrec, Clare J. Lee, Georgios K. Dimitriadis, Irina Jouravskaya, Adam Stefanski, W. Timothy Garvey   +6 more
wiley   +1 more source

The genetics of platelet count and volume in humans

Platelets, 2018
The last decade has witnessed an explosion in the depth, variety, and amount of human genetic data that can be generated. This revolution in technical and analytical capacities has enabled the genetic investigation of human traits and disease in ...
John D. Eicher, Guillaume Lettre, Andrew D. Johnson   +2 more
doaj   +1 more source

Association of Variability in Body Mass Index and Metabolic Health With Cardiometabolic Disease Risk

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background Metabolic syndrome is associated with high risk of cardiovascular disease, although risk may differ according to the specific conditions present and variability in those conditions. Methods and Results We defined obesity (body mass index [BMI]
Todd R. Sponholtz, Edwin R. van den Heuvel, Vanessa Xanthakis, Ramachandran S. Vasan   +3 more
doaj   +1 more source

The Epidemiology of Congestive Heart Failure: Contributions from the Framingham Heart Study

Global Heart, 2013
SummaryIn 1971, McKee et al. at the Framingham Heart Study published a seminal paper on the epidemiology of congestive heart failure. The authors proposed a set of standardized criteria for heart failure for use in research studies and described the risk factors for developing heart failure.
Syed S. Mahmood, Thomas J. Wang
openaire   +3 more sources