Results 131 to 140 of about 954,985 (333)

Cardiovascular Challenges in Chronic Lymphocytic Leukemia (CLL) Patients Undergoing Bruton Tyrosine Kinase (BTK) Inhibitor Therapy

European Journal of Haematology, EarlyView.
ABSTRACT Background/Objectives Bruton tyrosine kinase inhibitors (BTKis) have revolutionized treatment for chronic lymphocytic leukemia (CLL), but cardiovascular (CV) toxicities pose significant challenges. Second‐generation BTKis offer improved target specificity, yet CV risks persist.
Stefano Oliva, Stefano Molica
wiley   +1 more source

Relative Contributions of Arterial Stiffness and Hypertension to Cardiovascular Disease: The Framingham Heart Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
BackgroundThe presence and implications of abnormal arterial stiffness, a potential independent predictor of outcomes, in community‐dwelling treated hypertensives is unknown.
Teemu J. Niiranen, Bindu Kalesan, Naomi M. Hamburg, Emelia J. Benjamin, Gary F. Mitchell, Ramachandran S. Vasan   +5 more
doaj   +1 more source

Homocysteine levels and treatment effect in the prospective study of pravastatin in the elderly at risk [PDF]

, 2014
Objectives: To assess the effect of preventive pravastatin treatment on coronary heart disease (CHD) morbidity and mortality in older persons at risk for cardiovascular disease (CVD), stratified according to plasma levels of homocysteine.<p></p&
Assendelft, W.J.J., Blom, H.J., Blom, J.W., de Craen, A.J.M., de Ruijter, W., Drewes, Y.M., Ford, I., Gussekloo, J., Poortvliet, R.K.E., Sattar, N., Stott, D.J., Westendorp, R.G.J., Wouter Jukema, J.   +12 more
core   +3 more sources

Enantioselective comparative analysis of the anticonvulsant potency of fenfluramine and norfenfluramine in mice

Epilepsia, EarlyView.
Abstract Objective The in vivo effects of fenfluramine result from the combined actions of four active molecular entities (l‐fenfluramine, d‐fenfluramine, and the corresponding enantiomers of the primary metabolite norfenfluramine). Each of these compounds has different properties, with cardiovascular toxicity risk being ascribed primarily to the d ...
Yara Sheeni, Natalia Erenburg, Dinorah Barasch, Tawfeeq Shekh‐Ahmad, Emilio Perucca, Meir Bialer   +5 more
wiley   +1 more source

Application of Local Influence Diagnostics to the Linear Logistic Regression Models [PDF]

This paper focuses the development of the diagnostics for the perturbations of case-weights and explanatory variables (one or more) in a linear logistic regression model.
M. ATAHARUL ISLAM, MONZUR HOSSAIN
core  

Plasma Extracellular MicroRNAs Associated With Cardiovascular Disease Risk Factors in Middle‐Aged and Older Adults

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Extracellular microRNAs (miRNAs) are a class of noncoding RNAs that remain stable in the extracellular milieu, where they contribute to various physiological and pathological processes by facilitating intercellular signaling.
Hannah Karlin, Meera Sooda, Martin Larson, Jian Rong, Tianxiao Huan, Michelle M. J. Mens, Frank J. A. van Rooij, M. Arfan Ikram, Paul Courchesne, Jane E. Freedman, Roby Joehanes, Gregory P. Mueller, Maryam Kavousi, Mohsen Ghanbari, Daniel Levy   +14 more
doaj   +1 more source

Non-valvular atrial fibrillation and stroke : implications for management [PDF]

, 1995
Nonvalvular Atrial Fibrillation is more prevalent with increasing age. It is associated with a six-fold excess risk of stroke; and a cumulative lifetime stroke risk of 35%. 15% of ischaemic strokes are directly attributable to it.
Tilney, Myra Kay
core  

Screening for Osteoporosis in Nonagenarians: A Scoping Review

Journal of the American Geriatrics Society, EarlyView.
ABSTRACT Background As the United States population continues to age and advancements contribute to enhanced life expectancy, care for nonagenarians (adults aged 90 years and older) is as important as ever. A prominent concern within healthcare for the oldest old remains the occurrence of fragility fractures, and subsequent 1‐year mortality, making ...
Hannah A. Mosher, Hallie B. Remer, Kyra T. Berwitz, Giselle M. Hernandez, Marilyn Heng   +4 more
wiley   +1 more source

Epigenome-Wide Association Study of Soluble Tumor Necrosis Factor Receptor 2 Levels in the Framingham Heart Study

Frontiers in Pharmacology, 2018
Background: Transmembrane tumor necrosis factor (TNF) receptors are involved in inflammatory, apoptotic, and proliferative processes. In the bloodstream, soluble TNF receptor II (sTNFR2) can modify the inflammatory response of immune cells and is ...
Michael M. Mendelson, Michael M. Mendelson, Michael M. Mendelson, Roby Johannes, Chunyu Liu, Chunyu Liu, Tianxiao Huan, Tianxiao Huan, Chen Yao, Chen Yao, Xiao Miao, Joanne M. Murabito, Joanne M. Murabito, Josée Dupuis, Josée Dupuis, Daniel Levy, Daniel Levy, Emelia J. Benjamin, Emelia J. Benjamin, Emelia J. Benjamin, Honghuang Lin, Honghuang Lin   +21 more
doaj   +1 more source

Gene-environment interactions due to quantile-specific heritability of triglyceride and VLDL concentrations. [PDF]

, 2020
"Quantile-dependent expressivity" is a dependence of genetic effects on whether the phenotype (e.g., triglycerides) is high or low relative to its distribution in the population.
Williams, Paul T
core   +1 more source