Results 11 to 20 of about 879,424 (313)

Expression quantitative trait methylation analysis elucidates gene regulatory effects of DNA methylation: the Framingham Heart Study

Scientific Reports, 2023
Expression quantitative trait methylation (eQTM) analysis identifies DNA CpG sites at which methylation is associated with gene expression. The present study describes an eQTM resource of CpG-transcript pairs derived from whole blood DNA methylation and ...
Amena Keshawarz, Helena Bui, Roby Joehanes, Jiantao Ma, Chunyu Liu, Tianxiao Huan, Shih-Jen Hwang, Brandon Tejada, Meera Sooda, Paul Courchesne, Peter J. Munson, Cumhur Y. Demirkale, Chen Yao, Nancy L. Heard-Costa, Achilleas N. Pitsillides, Honghuang Lin, Ching-Ti Liu, Yuxuan Wang, Gina M. Peloso, Jessica Lundin, Jeffrey Haessler, Zhaohui Du, Michael Cho, Craig P. Hersh, Peter Castaldi, Laura M. Raffield, Jia Wen, Yun Li, Alexander P. Reiner, Mike Feolo, Nataliya Sharopova, Ramachandran S. Vasan, Dawn L. DeMeo, April P. Carson, Charles Kooperberg, Daniel Levy   +35 more
doaj   +1 more source

Copy number variation in the Framingham Heart Study [PDF]

BMC Proceedings, 2009
Abstract In this paper we test for association between copy number variation and diabetes in a subset of individuals from the Framingham Heart Study. We used the 500 k SNP data and called copy number variation using two algorithms: the genome alteration detection algorithm of Pique-Regi et al. and the software Golden Helix. We then tested for
Fredrick R. Schumacher, Corina Shtir, Paul Marjoram, Roger Pique-Regi, Kim Siegmund, John Morrison   +5 more
openaire   +3 more sources

Epigenome-wide association study of DNA methylation and microRNA expression highlights novel pathways for human complex traits

Epigenetics, 2020
DNA methylation (DNAm) and microRNAs (miRNAs) have been implicated in a wide-range of human diseases. While often studied in isolation, DNAm and miRNAs are not independent. We analyzed associations of expression of 283 miRNAs with DNAm at >400K CpG sites
Tianxiao Huan, Michael Mendelson, Roby Joehanes, Chen Yao, Chunyu Liu, Ci Song, Anindya Bhattacharya, Jian Rong, Kahraman Tanriverdi, Joshua Keefe, Joanne M. Murabito, Paul Courchesne, Martin G. Larson, Jane E. Freedman, Daniel Levy   +14 more
doaj   +1 more source

Pedigree and genotype errors in the Framingham Heart Study [PDF]

BMC Genetics, 2003
AbstractThe pedigree and genotype data from the Framingham Heart Study were examined for errors. Errors in 21 of 329 pedigrees were detected with the program PREST, and of these the errors in 16 pedigrees were resolved. Genotyping errors were then detected with SIMWALK2. Five Mendelian errors were found following the pedigree corrections.
Gerry Brush, Laura Almasy
openaire   +3 more sources

Transmission-ratio distortion in the Framingham Heart Study [PDF]

BMC Proceedings, 2009
Transmission-ratio distortion (TRD) is a phenomenon in which the segregation of alleles does not obey Mendel's laws. As a simple example, a recessive locus that results in fetal lethality will result in live-born individuals sharing more alleles at this locus than expected under Mendel's laws.
Andrew D. Paterson, Claire Infante-Rivard, Dushanthi Pinnaduwage, Arne Schillert, Shelley B. Bull, Shelley B. Bull, Daryl Waggott, Yun Joo Yoo   +7 more
openaire   +4 more sources

Noninvasive tests for nonalcoholic fatty liver disease in a multi‐ethnic population: The HELIUS study

Hepatology Communications, EarlyView., 2022
Abstract Nonalcoholic fatty liver disease (NAFLD) is increasing in prevalence and severity globally, prompting noninvasive testing, yet limited data exist on noninvasive liver tests (NITs) including transient elastography (TE) in ethnically diverse populations.
Anne‐Marieke van Dijk, Yasaman Vali, Anne Linde Mak, Henrike Galenkamp, Max Nieuwdorp, Bert‐Jan van den Born, Adriaan Georgius Holleboom   +6 more
wiley   +1 more source

Neck Circumference and Risk of Incident Atrial Fibrillation in the Framingham Heart Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022
Background Increased neck circumference, a proxy for upper‐body subcutaneous fat, is associated with cardiovascular risk and metabolic risk factors, accounting for body mass index (BMI) and waist circumference.
Jelena Kornej, Honghuang Lin, Ludovic Trinquart, Corban R. Jackson, Darae Ko, Emelia J. Benjamin, Sarah R. Preis   +6 more
doaj   +1 more source

Association of Life's Essential 8 With Cardiovascular Disease and Mortality: The Framingham Heart Study

Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease, 2023
Background The association of the American Heart Association's updated cardiovascular health score, the Life's Essential 8 (LE8), with cardiovascular disease (CVD) and death is not described in the FHS (Framingham Heart Study).
Athanasios Rempakos, Brenton R. Prescott, G. Mitchell, Ramachandran S. Vasan, V. Xanthakis   +4 more
semanticscholar   +1 more source

Trends in Diabetes Incidence: The Framingham Heart Study [PDF]

Diabetes Care, 2014
OBJECTIVE Obesity and type 2 diabetes continue to increase in prevalence in the U.S. Whether diabetes incidence continues to increase in recent times is less well documented. We examined trends in diabetes incidence over the previous four decades. RESEARCH DESIGN AND
Tobin M. Abraham, Caroline S. Fox, Caroline S. Fox, Michael J. Pencina, Karol M. Pencina   +4 more
openaire   +3 more sources

Premature Parental Cardiovascular Disease and Subclinical Disease Burden in the Offspring

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background Offspring of parents with premature cardiovascular disease (CVD) have an increased risk of developing subclinical and clinical CVD. It is unclear whether this association differs by vascular beds in the offspring or by the age cut points used ...
Wolfgang Lieb, Rebecca J. Song, Ramachandran S. Vasan, Vanessa Xanthakis   +3 more
doaj   +1 more source