Results 21 to 30 of about 879,424 (313)

Epidemiology of venous thromboembolism in the Framingham Heart Study [PDF]

Thrombosis Research, 2016
Reports of the crude incidence of venous thromboembolism (VTE) in Western countries vary widely. Data regarding risk factors, incidence and recurrence of VTE from deeply-phenotyped community-based cohort studies are needed.To study the incidence, associated mortality, and predisposing factors of VTE in the prospective, longitudinal community-based ...
Jared W. Magnani, Marja K. Puurunen, Martin G. Larson, Philimon Gona, Joanne M. Murabito, Christopher J. O'Donnell, Christopher J. O'Donnell   +6 more
openaire   +2 more sources

Circulating ceramide ratios and risk of vascular brain aging and dementia

Annals of Clinical and Translational Neurology, 2020
Background We determined the association between ratios of plasma ceramide species of differing fatty‐acyl chain lengths and incident dementia and Alzheimer’s disease (AD) dementia in a large, community‐based sample.
Emer R. McGrath, Jayandra J. Himali, Vanessa Xanthakis, Meredith S. Duncan, Jean E. Schaffer, Daniel S. Ory, Linda R. Peterson, Charles DeCarli, Matthew P. Pase, Claudia L. Satizabal, Ramachandran S. Vasan, Alexa S. Beiser, Sudha Seshadri   +12 more
doaj   +1 more source

Causal Effect of Plasminogen Activator Inhibitor Type 1 on Coronary Heart Disease

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundPlasminogen activator inhibitor type 1 (PAI‐1) plays an essential role in the fibrinolysis system and thrombosis. Population studies have reported that blood PAI‐1 levels are associated with increased risk of coronary heart disease (CHD ...
Ci Song, Stephen Burgess, John D. Eicher, Christopher J. O'Donnell, Andrew D. Johnson   +4 more
doaj   +1 more source

Consent for genetic research in the Framingham Heart Study [PDF]

American Journal of Medical Genetics Part A, 2010
AbstractExtensive efforts have been aimed at understanding the genetic underpinnings of complex diseases that affect humans. Numerous genome‐wide association studies have assessed the association of genes with human disease, including the Framingham Heart Study (FHS), which genotyped 550,000 SNPs in 9,000 participants.
Ralph B. D'Agostino, Ralph B. D'Agostino, Elizabeth J. Oberacker, Patrice Sutherland, Joanne M. Murabito, Joanne M. Murabito, Christopher J. O'Donnell, L. Adrienne Cupples, L. Adrienne Cupples, Daniel Levy, Greta Lee Splansky, Karen Mutalik, Larry D. Atwood, Larry D. Atwood, Maureen Valentino, Margaret Kelly-Hayes, Margaret Kelly-Hayes, Greg Koski, Philip A. Wolf, Philip A. Wolf, Ramachandran S. Vasan, Ramachandran S. Vasan, Nicolle K. Strand, Caroline S. Fox, Martin G. Larson, Martin G. Larson, Susan J. Blease, Emelia J. Benjamin, Emelia J. Benjamin   +28 more
openaire   +2 more sources

Circulating IGFBP‐2: a novel biomarker for incident dementia

Annals of Clinical and Translational Neurology, 2019
Objective To determine the association between plasma insulin‐like growth factor binding protein 2 (IGFBP‐2) and cognitive outcomes. Methods We measured plasma IGFBP‐2 levels in 1596 (53% women, mean age 68.7 [SD 5.7] years) dementia‐free Framingham ...
Emer R. McGrath, Jayandra J. Himali, Daniel Levy, Sarah C. Conner, Charles S. DeCarli, Matthew P. Pase, Paul Courchesne, Claudia L. Satizabal, Ramachandran S. Vasan, Alexa S. Beiser, Sudha Seshadri   +10 more
doaj   +1 more source

Arterial Stiffness and Diabetes Risk in Framingham Heart Study and UK Biobank

Circulation Research, 2022
Background: Microvascular damage from large artery stiffness (LAS) in pancreatic, hepatic, and skeletal muscles may affect glucose homeostasis. Our goal was to evaluate the association between LAS and the risk of type 2 diabetes using prospectively ...
Jordana B. Cohen, G. Mitchell, D. Gill, S. Burgess, Mahboob Rahman, T. Hanff, V. Ramachandran, K. Mutalik, R. Townsend, J. Chirinos   +9 more
semanticscholar   +1 more source

Contemporary Trends in Dyslipidemia in the Framingham Heart Study [PDF]

Archives of Internal Medicine, 2009
Recent cross-sectional population studies in the United States have shown an increase in obesity, a decrease in cholesterol values, but no changes in levels of high-density lipoprotein cholesterol (HDL-C) or triglycerides (TG).Plasma total cholesterol, HDL-C, and TG levels, measured by the same methods at the 3 most recently completed examinations of ...
Joseph M. Massaro, Erik Ingelsson, Patrice Sutherland, Paul F. Jacques, Sander J. Robins, Ramachandran S. Vasan, Daniel Levy, Ralph B. D'Agostino   +7 more
openaire   +3 more sources

Self-Reported Physical Activity and Relations to Growth and Neurotrophic Factors in Diabetes Mellitus: The Framingham Offspring Study

Journal of Diabetes Research, 2019
Aims. Circulating insulin-like growth factor- (IGF-) 1, vascular endothelial growth factor (VEGF), and brain-derived neurotrophic factor (BDNF) levels are often lower in individuals with diabetes mellitus (DM) and are important for repairing vascular and
Nicole L. Spartano, Kendra L. Davis-Plourde, Jayandra J. Himali, Joanne M. Murabito, Ramachandran S. Vasan, Alexa S. Beiser, Sudha Seshadri   +6 more
doaj   +1 more source

Arterial Stiffness and Long-Term Risk of Health Outcomes: The Framingham Heart Study

HYPERTENSION, 2022
Background: Arterial stiffness increases with age and is associated with an increased risk of adverse outcomes on short-term follow-up (typically
R. Vasan, Stephanie Pan, V. Xanthakis, A. Beiser, M. Larson, S. Seshadri, G. Mitchell   +6 more
semanticscholar   +1 more source

Clinical relevance of double‐arm blood pressure measurement and prevalence of clinically important inter‐arm blood pressure differences in Indian Primary Care

The Journal of Clinical Hypertension, Accepted Article., 2022
Abstract Hypertension guidelines recommend measuring blood pressure (BP) in both arms at least once. However, this is seldom done due to uncertainties regarding measurement procedure and the implications of finding a clinically important inter‐arm BP difference (IAD).
Gurpreet S. Wander, Sinead T.J. McDonagh, M. Srinivasa Rao, R. Alagesan, JC Mohan, Ajit Bhagwat, AK Pancholia, M. Viswanathan, Manoj Bhavrilal Chopda, A Purnanand, PLN kapardhi, Arun R Vadavi, R Selvaraj, Pankaj Aneja, Suhas Hardas, Neil Bordoloi, N Sivakadaksham, Christopher E goswami, Christopher E Clark, Willem J. Verberk   +19 more
wiley   +1 more source