Results 21 to 30 of about 972,269 (340)

Circulating ceramide ratios and risk of vascular brain aging and dementia

Annals of Clinical and Translational Neurology, 2020
Background We determined the association between ratios of plasma ceramide species of differing fatty‐acyl chain lengths and incident dementia and Alzheimer’s disease (AD) dementia in a large, community‐based sample.
Emer R. McGrath, Jayandra J. Himali, Vanessa Xanthakis, Meredith S. Duncan, Jean E. Schaffer, Daniel S. Ory, Linda R. Peterson, Charles DeCarli, Matthew P. Pase, Claudia L. Satizabal, Ramachandran S. Vasan, Alexa S. Beiser, Sudha Seshadri   +12 more
doaj   +1 more source

Causal Effect of Plasminogen Activator Inhibitor Type 1 on Coronary Heart Disease

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundPlasminogen activator inhibitor type 1 (PAI‐1) plays an essential role in the fibrinolysis system and thrombosis. Population studies have reported that blood PAI‐1 levels are associated with increased risk of coronary heart disease (CHD ...
Ci Song, Stephen Burgess, John D. Eicher, Christopher J. O'Donnell, Andrew D. Johnson   +4 more
doaj   +1 more source

Association of Life's Essential 8 With Cardiovascular Disease and Mortality: The Framingham Heart Study

Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease, 2023
Background The association of the American Heart Association's updated cardiovascular health score, the Life's Essential 8 (LE8), with cardiovascular disease (CVD) and death is not described in the FHS (Framingham Heart Study).
Athanasios Rempakos, Brenton R. Prescott, G. Mitchell, Ramachandran S. Vasan, V. Xanthakis   +4 more
semanticscholar   +1 more source

Circulating IGFBP‐2: a novel biomarker for incident dementia

Annals of Clinical and Translational Neurology, 2019
Objective To determine the association between plasma insulin‐like growth factor binding protein 2 (IGFBP‐2) and cognitive outcomes. Methods We measured plasma IGFBP‐2 levels in 1596 (53% women, mean age 68.7 [SD 5.7] years) dementia‐free Framingham ...
Emer R. McGrath, Jayandra J. Himali, Daniel Levy, Sarah C. Conner, Charles S. DeCarli, Matthew P. Pase, Paul Courchesne, Claudia L. Satizabal, Ramachandran S. Vasan, Alexa S. Beiser, Sudha Seshadri   +10 more
doaj   +1 more source

Gut microbiome and metabolome profiling in Framingham heart study reveals cholesterol-metabolizing bacteria [PDF]

Cell
Chenhao Li, Martin Stražar, Ahmed M. Mohamed, Julián Ávila-Pacheco, Rebecca L. Walker, Tina Lebar, Shijie Zhao, Julia Lockart, Andrea Dame, Kumar Thurimella, Sarah Jeanfavre, Eric Brown, Qi Yan Ang, Brittany Berdy, Dallis Sergio, Rachele Invernizzi, Antonio Tinoco, Gleb Pishchany, Ramachandran S. Vasan, Emily P. Balskus, Curtis Huttenhower, Hera Vlamakis, Clary B. Clish, Stanley Y. Shaw, Damian R. Plichta, Ramnik J. Xavier   +25 more
openalex   +2 more sources

Association between noninvasive fibrosis markers and cardio-vascular organ damage among adults with hepatic steatosis [PDF]

, 2014
Evidence suggests that advanced fibrosis, as determined by the noninvasive NAFLD fibrosis score (NFS), is a predictor of cardiovascular mortality in individuals with ultrasonography-diagnosed NAFLD. Whether the severity of histology (i.e., fibrosis stage)
Fiorentino, Tv, Perticone, F, Perticone, M, Sciacqua, A, Sesti, G, Succurro, E   +5 more
core   +6 more sources

Depression is associated with higher t‐tau level in plasma: a report from the Framingham Heart Study [PDF]

Alzheimers Dement
Carlos Gaona, Vanessa M. Young, Crystal Wiedner, Arash Salardini, A. Ballano Ruiz, Rebecca Bernal, Alexa S Beiser, Jayandra J. Himali, Sudha Seshadri, Antonio L. Teixeira   +9 more
openalex   +2 more sources

Transmission-ratio distortion in the Framingham Heart Study [PDF]

BMC Proceedings, 2009
Transmission-ratio distortion (TRD) is a phenomenon in which the segregation of alleles does not obey Mendel's laws. As a simple example, a recessive locus that results in fetal lethality will result in live-born individuals sharing more alleles at this locus than expected under Mendel's laws.
Paterson, Andrew D, Waggott, Daryl, Schillert, Arne, Infante-Rivard, Claire, Bull, Shelley B, Yoo, Yun J, Pinnaduwage, Dushanthi   +6 more
openaire   +3 more sources

Self-Reported Physical Activity and Relations to Growth and Neurotrophic Factors in Diabetes Mellitus: The Framingham Offspring Study

Journal of Diabetes Research, 2019
Aims. Circulating insulin-like growth factor- (IGF-) 1, vascular endothelial growth factor (VEGF), and brain-derived neurotrophic factor (BDNF) levels are often lower in individuals with diabetes mellitus (DM) and are important for repairing vascular and
Nicole L. Spartano, Kendra L. Davis-Plourde, Jayandra J. Himali, Joanne M. Murabito, Ramachandran S. Vasan, Alexa S. Beiser, Sudha Seshadri   +6 more
doaj   +1 more source

Ceramide remodeling and risk of cardiovascular events and mortality [PDF]

, 2018
BackgroundRecent studies suggest that circulating concentrations of specific ceramide species may be associated with coronary risk and mortality. We sought to determine the relations between the most abundant plasma ceramide species of differing acyl ...
Dorr, Marcus, Duncan, Meredith S, Felix, Stephan B, Friedrich, Nele, Gross, Stefan, Jiang, Hui, Jiang, Xuntian, Nauck, Matthias, Ory, Daniel S, Peterson, Linda R, Shaffer, Jean E, Sidhu, Rohini, Vasan, Ramachandran S, Volzke, Henry, Xanthakis, Vanessa   +14 more
core   +2 more sources