Results 71 to 80 of about 972,269 (340)

Carotid Atherosclerosis and Cerebral Microbleeds: The Framingham Heart Study [PDF]

Journal of the American Heart Association, 2016
Background Carotid atherosclerosis is associated with subclinical ischemic cerebrovascular disease, but its role in hemorrhage‐prone small vessel disease—represented by cerebral microbleed ( CMB )—is unclear, although vascular risk factors underlie both conditions. We hypothesized that
Romero, José R, Preis, Sarah R, Beiser, Alexa, DeCarli, Charles, D'Agostino, Ralph B, Wolf, Philip A, Vasan, Ramachandran S, Polak, Joseph F, Seshadri, Sudha   +8 more
openaire   +5 more sources

Integrated In Vitro, In Vivo, and In Silico Study Reveals Gut‐Protective Effects of Myricitrin From Chinese Bayberry Leaves

Food Frontiers, EarlyView.
High‐purity myricitrin from Chinese bayberry leaves alleviates colonic inflammation by preserving epithelial barrier integrity and reshaping gut microbiota composition. ABSTRACT Polyphenols have been widely recognized for their ability to modulate the host inflammatory response and orchestrate the intestinal microenvironment.
Ji‐Min Lv, Wei Quan, Xiao‐Hua Cheng, Jing Zhu, Aliyu Idris Muhammad, Wang‐Ting Zhou, Xing‐Jiang Qi, Chong‐De Sun   +7 more
wiley   +1 more source

Consent for genetic research in the Framingham Heart Study [PDF]

American Journal of Medical Genetics Part A, 2010
AbstractExtensive efforts have been aimed at understanding the genetic underpinnings of complex diseases that affect humans. Numerous genome‐wide association studies have assessed the association of genes with human disease, including the Framingham Heart Study (FHS), which genotyped 550,000 SNPs in 9,000 participants.
Daniel, Levy, Greta Lee, Splansky, Nicolle K, Strand, Larry D, Atwood, Emelia J, Benjamin, Susan, Blease, L Adrienne, Cupples, Ralph B, D'Agostino, Caroline S, Fox, Margaret, Kelly-Hayes, Greg, Koski, Martin G, Larson, Karen M, Mutalik, Elizabeth, Oberacker, Christopher J, O'Donnell, Patrice, Sutherland, Maureen, Valentino, Ramachandran S, Vasan, Philip A, Wolf, Joanne M, Murabito   +19 more
openaire   +2 more sources

Distribution, determinants and normal reference values of aortic arch width: Thoracic aortic geometry in the Framingham Heart Study

American Heart Journal Plus, 2023
Study objective: Aortic arch geometry changes with age, including an increase in aortic arch width (AAW). High AAW is a predictor of incident adverse cardiovascular disease (CVD) events, but its distribution and determinants are unknown.
Saadia Qazi, Philimon N. Gona, Rebecca M. Musgrave, Caroline S. Fox, Joseph M. Massaro, Udo Hoffmann, Michael L. Chuang, Christopher J. O'Donnell   +7 more
doaj   +1 more source

Critical appraisal of CRP measurement for the prediction of coronary heart disease events: new data and systematic review of 31 prospective cohorts. [PDF]

, 2008
BACKGROUND: Non-uniform reporting of relevant relationships and metrics hampers critical appraisal of the clinical utility of C-reactive protein (CRP) measurement for prediction of later coronary events.
Casas, Juan P, Cooper, Jackie A, Deanfield, John E, Fowkes, F Gerald R, Hingorani, Aroon D, Humphries, Steve E, Lowe, Gordon D, McCormack, Valerie, Rumley, Ann, Shah, Tina, Smeeth, Liam, Sofat, Reecha, Tzoulaki, Ioanna   +12 more
core   +2 more sources

Lifetime risk of atrial fibrillation according to optimal, borderline, or elevated levels of risk factors: cohort study based on longitudinal data from the Framingham Heart Study

British medical journal, 2018
Objective To examine the association between risk factor burdens—categorized as optimal, borderline, or elevated—and the lifetime risk of atrial fibrillation. Design Community based cohort study. Setting Longitudinal data from the Framingham Heart Study.
L. Staerk, Biqi Wang, S. Preis, M. Larson, S. Lubitz, P. Ellinor, D. McManus, D. Ko, L. Weng, K. Lunetta, L. Frost, E. Benjamin, L. Trinquart   +12 more
semanticscholar   +1 more source

Reversal of aging-induced increases in aortic stiffness by targeting cytoskeletal protein-protein interfaces [PDF]

, 2018
BACKGROUND: The proximal aorta normally functions as a critical shock absorber that protects small downstream vessels from damage by pressure and flow pulsatility generated by the heart during systole.
Chiu, Joanna, Gao, Yuan, Leavis, Paul, Li, Qian, Mitchell, G. F., Morgan, Kathleen, Nicholson, Christopher, Porter, Tyrone, Saphirstein, Robert, Singh, Kuldeep, Verwoert, Germaine   +10 more
core   +1 more source

Establishing cognitive baseline in three generations: Framingham Heart Study

Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 2023
AbstractIntroductionGenerational changes warrant recalibrating normative cognitive measures to detect changes indicative of dementia risk within each generation.MethodsWe performed linear regressions to compare eight neuropsychological (NP) tests among three‐generation cohorts at baseline in Framingham Heart Study (FHS, n = 4787) and conducted Cox ...
Jin Yang, Ting Fang Alvin Ang, Sophia Lu, Xue Liu, Sherral Devine, Rhoda Au, Chunyu Liu   +6 more
openaire   +3 more sources

Population Pharmacokinetics and Transfer of Gabapentin When Used as a Pain Adjunct for Cesarean Deliveries

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 551-560, March 2025.
ABSTRACT Enhanced Recovery After Surgery (ERAS) protocols for cesarean deliveries (CDs) utilize multimodal pain management strategies that often include gabapentin. While gabapentin is excreted in breast milk, its pharmacokinetics in immediately postpartum lactating women are not known. This observational pharmacokinetic study (NCT05099484) enrolled 21
Rebecca Silvola, Aislinn O'Kane, Michael Heathman, Hannah Marotta, Hayley Trussel, Bobbie Ray, Shelley Dowden, Andrea R. Masters, David M. Haas, Sara K. Quinney   +9 more
wiley   +1 more source

Assessment of Incidence and Risk Factors of Intracerebral Hemorrhage Among Participants in the Framingham Heart Study Between 1948 and 2016.

JAMA Neurology, 2020
Importance Intracerebral hemorrhage (ICH) has the highest mortality of all stroke types and is the most serious complication of anticoagulation. Data regarding trends in ICH incidence and location-specific risk factors on the population level are ...
V. Lioutas, A. Beiser, H. Aparicio, J. Himali, M. Selim, J. Romero, S. Seshadri   +6 more
semanticscholar   +1 more source