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The interplay between the marine diazotroph Vibrio diazotrophicus and its prophage shapes both biofilm structure and nitrogen release [PDF]
Applied and Environmental MicrobiologyMarine environments are frequently oligotrophic, characterized by low amount of bioassimilable nitrogen sources. At the global scale, the microbial fixation of N₂, or diazotrophy, represents the primary source of fixed nitrogen in pelagic marine ...Louise Mahoudeau, Pauline Crétin, Aurélie Joublin-Delavat, Sophie Rodrigues, Clara Guillouche, Isabelle Louvet, Nadège Bienvenu, Claire Geslin, Gabriel Dulaquais, Jean-François Maguer, François Delavat +10 moredoaj +2 more sourcesTolerance and efficacy of targeted therapies prescribed for off-label indications in refractory systemic autoimmune diseases: data of the first 100 patients enrolled in the TATA registry (TArgeted Therapy in Autoimmune Diseases) [PDF]
RMD Open, 2022 Objectives To assess the tolerance and efficacy of targeted therapies prescribed off-label in refractory low-prevalence autoimmune and inflammatory systemic diseases.Methods The TATA registry (TArgeted Therapy in Autoimmune Diseases) is a prospective ...Patrice Cacoub, Arsène Mekinian, Zahir Amoura, Eric Hachulla, Yves Allenbach, Renaud Felten, Anne-Sophie Korganow, Christelle Sordet, Aurélien Guffroy, Xavier Mariette, Christophe Richez, Jacques-Eric Gottenberg, Alain Meyer, Jean Sibilia, Benjamin Terrier, Emmanuel Chatelus, Laurence Bouillet, Marie-Elise Truchetet, Isabelle Melki, Divi Cornec, Martin Michaud, Raphaele Seror, Bénédicte Rouvière, Pierre Quartier, Sebastien Ottaviani, Julien Henry, Valérie Devauchelle-Pensec, Claire Larroche, Azeddine Dellal, Marie Desmurs, Mathieu Jouvray, Hubert Nielly, Antoine Poulet, Guillaume Vial, Roland Jaussaud, Boris Bienvenu, Pierre-Yves Jeandel, Jean-François Kleinmann, Emeline Gaigneux, Aurélie Saunier, Amelie Leurs, Aurore Chaudier, Marc Gatfosse, Vincent Andre, Gildas Baulier, Mathieu Ete, Samira Litim-Ahmed-Yahia +46 moredoaj +2 more sourcesDomestic Activities Associated With a Decreased Risk of Cognitive Disorders: Results of the “Fréle” Cohort [PDF]
Frontiers in Public Health, 2020 Background: Previous cohorts studied the association of various types of physical activities with the incidence of cognitive disorders. The objective of this work was to analyze the association of leisure, domestic and professional physical activities ...Caroline Dupré, Caroline Dupré, Caroline Dupré, David Hupin, Luc Goethals, Luc Goethals, François Béland, François Béland, Frédéric Roche, Thomas Célarier, Isabelle Carrière, Nathalie Barth, Nathalie Barth, Bienvenu Bongue, Bienvenu Bongue, Bienvenu Bongue +15 moredoaj +2 more sourcesAssociation between voriconazole exposure and Sequential Organ Failure Assessment (SOFA) score in critically ill patients. [PDF]
PLoS ONE, 2021 Therapeutic drug monitoring (TDM) is essential for voriconazole to ensure optimal drug exposure, mainly in critically ill patients for whom voriconazole demonstrated a large variability.Anne-Lise Bienvenu, Pierre Pradat, Alexandra Plesa, Vincent Leclerc, Vincent Piriou, Jean-Luc Fellahi, Laurent Argaud, Thomas Rimmelé, Jean Menotti, Frédéric Aubrun, Jean-Christophe Richard, Marie-Claude Gagnieu, François Parant, Christian Chidiac, Gilles Leboucher, Michel Tod, Sylvain Goutelle +16 moredoaj +2 more sourcesEfficacy and safety of anakinra in adults presenting deteriorating respiratory symptoms from COVID-19: A randomized controlled trial [PDF]
PLoS ONE, 2022 Objective We aimed to investigate whether anakinra, an interleukin-1receptor inhibitor, could improve outcome in moderate COVID-19 patients. Methods In this controlled, open-label trial, we enrolled adults with COVID-19 requiring oxygen.Alexandra Audemard-Verger, Amélie Le Gouge, Vincent Pestre, Johan Courjon, Vincent Langlois, Marc-Olivier Vareil, Mathilde Devaux, Boris Bienvenu, Vincent Leroy, Radjiv Goulabchand, Léa Colombain, Adrien Bigot, Thomas Guimard, Youcef Douadi, Geoffrey Urbanski, Jean François Faucher, Laurence Maulin, Bertrand Lioger, Jean-Philippe Talarmin, Matthieu Groh, Joseph Emmerich, Sophie Deriaz, Nicole Ferreira-Maldent, Ann-Rose Cook, Céline Lengellé, Hélène Bourgoin, Arsène Mekinian, Achille Aouba, François Maillot, Agnès Caille +29 moredoaj +3 more sourcesMolecular characterization of potential Plasmodium-Blocking Serratia spp. bacteria in field-caught malaria mosquito in Burkina Faso [PDF]
Parasites & VectorsBackground One of the alternatives for controlling malaria is using mosquito symbiotic bacteria to reduce Plasmodium transmission. Species of Serratia , a genus of the Enterobacteriaceae family, have been isolated from the midgut of mosquitoes and are ...Haoua Traoré, Edounou Jacques Gnambani, Domonbabele François de Sales Hien, Raymond Karlhis Yao, Maurice Konkobo, Aicha Fatimata Sodré, Martin Bienvenu Somda, Abdoul Salam Ouedraogo, Abdoulaye Diabaté, Etienne Bilgo +9 moredoaj +2 more sourcesImprovement of Treg immune response after treatment with tocilizumab in giant cell arteritis [PDF]
Clinical & Translational Immunology, 2021 Objectives To study the percentage, suppressive function and plasticity of Treg in giant cell arteritis (GCA), and the effects of glucocorticoids and tocilizumab.Maxime Samson, Hélène Greigert, Marion Ciudad, Claire Gerard, Thibault Ghesquière, Malika Trad, Marc Corbera‐Bellalta, Coraline Genet, Sethi Ouandji, Claudie Cladière, Marine Thebault, Kim Heang Ly, Eric Liozon, François Maurier, Boris Bienvenu, Benjamin Terrier, Loïc Guillevin, Pierre Charles, Valérie Quipourt, Hervé Devilliers, Pierre‐Henry Gabrielle, Catherine Creuzot‐Garcher, Georges Tarris, Laurent Martin, Philippe Saas, Sylvain Audia, Maria Cinta Cid, Bernard Bonnotte +27 moredoaj +2 more sourcesNSAID exposure delays time-to-pregnancy in patients with spondyloarthritis: an analysis of the GR2 prospective cohort [PDF]
RMD OpenBackground The impact of disease activity and treatment on fertility outcomes in patients with spondyloarthritis (SpA) has been little explored. This study aimed to describe median time to pregnancy (TTP) in women with SpA and the factors influencing TTP , Beatrice Banneville, Arsène Mekinian, Jérémie Sellam, François Goffinet, Maxime Dougados, Eric Hachulla, Nathalie Costedoat-Chalumeau, Laure Gossec, Anna Molto, Frédéric Lioté, Emmanuel Maheu, Amélie Denis, Anne-Sophie Korganow, Christelle Sordet, Emmanuelle Dernis, Martin Soubrier, Xavier Mariette, Christophe Richez, Benjamin Chaigne, Hubert Marotte, Laurent Perard, Olivier Fain, Nicolas Schleinitz, Patrick Jégo, Elisabeth Pasquier, Sabine Berthier, Claire Grange, Marc Lambert, Jonathan London, Hélène Maillard, François Maurier, Alexis Régent, Vincent Sobanski, Grégory Pugnet, Emmanuel Chatelus, Jacques Morel, Rene-Marc Flipo, Emanuelle Dernis, Alban Deroux, Marc Fabre, Marion Couderc, Nihal Martis, Martin Michaud, Raphaele Seror, Sophie Georgin-Lavialle, Léa Savey, Hervé Levesque, Jean-Loup Pennaforte, Rakiba Belkhir, Maria Letizia Urban, Sandra Desouches, Elisabeth Gervais, Augustin Latourte, Aline Frazier, Sabrina Hamroun, Matthieu Mahevas, Bertrand Godeau, Marc Michel, Cédric Lukas, Pascal Cathébras, Geoffrey Urbanski, Holy Bezanahary, Cecile Yelnik, Ygal Benhamou, Thierry Thomas, Nicolas Martin-Silva, Gaëlle Leroux, Veronique Le Guern, Claire Larroche, Azeddine Dellal, Guillaume Moulis, Emilie Berthoux, Fleur Cohen, Guillaume Direz, Nicole Ferreira-Maldent, Antoine Froissart, Vincent Langlois, Agnès Portier, Mélanie Roriz, Boris Bienvenu, Alice Berezne, Claire Cazalets, Aurelie Hummel, Pascal Coquerelle, Laurence Loeuillet, Noémie Jourde-Chiche, Claire Blanchard-Delaunay, Moez Jallouli, Cristina Belizna, Isabelle Durieu, Gaëlle Guettrot-Imbert, Catherine Deneux-Tharaux, Elisabeth Elefant, Laetitia Dunogeant, Anne Gompel, Lisa Biale, Agathe Masseau, Elodie Chauvet, Juliette Delforge, Christian Lavigne, Marie-Agnès Timsit, Delphine Lariviere, Evangeline Pillebout, Antoinette Perlat, Jean-Maxime Piot, Vassilis Tsatsaris, Mathilde de Menthon, Claire de Moreuil, Gaetan Sauvetre, Loïc Raffray, Jeremy Ora, Celine Lartigau-Roussin, Nathalie Tieulé, Sara Melboucy-Belkhir, Antoine Baudet, Constance Beaudouin-Bazire, Anne Calas, Olivia Chandesris, Jérémy Chatelais, Marine Driessen, Aurélie Du Thanh, Cécile Durant, Phillipe Goupille, Constance Guillaud-Danis, Stéphane Jobard, Laurence Josselin-Mahr, Thomas Le Gallou, Valentine Loustau, Hélène Petit Bauer, Vincent Poindron Geneviève Plu-Bureau, Jeremy Sellam, Katia Stankovic-Stojanovic +132 moredoaj +2 more sourcesTocilizumab plus dexamethasone versus dexamethasone in patients with moderate-to-severe COVID-19 pneumonia: A randomised clinical trial from the CORIMUNO-19 study group [PDF]
EClinicalMedicine, 2022 Summary: Background: In moderate-to-severe COVID-19 pneumonia, dexamethasone (DEX) and tocilizumab (TCZ) reduce the occurrence of death and ventilatory support.Olivier Hermine, Xavier Mariette, Raphael Porcher, Felix Djossou, Yann Nguyen, Jean-Benoît Arlet, Laurent Savale, Jean Luc Diehl, Sophie Georgin-Lavialle, Jacques Cadranel, Gilles Pialoux, Karine Lacombe, Arsène Mekinian, Hélène Gros, Xavier Lescure, Jade Ghosn, Elisabeth Coupez, Kevin Grapin, Christophe Rapp, Marc Michel, Anne Lise Lecapitaine, Jean Marie Michot, Nathalie Costedoat-Chalumeau, Liem Binh Luong Nguyen, Luca Semerano, François Raffi, Claire Aguillar, Claire Rouzaud, Jacques Eric Gottenberg, Yves Hansmann, Boris Bienvenu, Jonathan London, Franklin Samou Fantchou, Felix Ackermann, Antoine Gros, Alexandre Morel, Nicolas Gambier, Damien Sène, Bruno Mégarbane, Elie Azoulay, Serge Bureau, Maxime Dougados, Joseph Emmerich, Muriel Fartoukh, Bertrand Guidet, Marc Humbert, Mathieu Mahevas, Frédéric Pène, Frédéric Schlemmer, Valérie Pourcher-Martinez, Annick Tibi, Gabriel Baron, Elodie Perrodeau, Stéphanie Baron, Gabriel Steg, Yazdan Yazdapanah, Tabassome Simon, Matthieu Resche-Rigon, Pierre-Louis Tharaux, Philippe Ravaud +59 moredoaj +2 more sourcesSPACO+: a mixed methods protocol to assessing the effectiveness of an educative intervention in patients with Long Covid [PDF]
BMC Infectious DiseasesBackground The management of many chronic diseases requires a multidisciplinary and holistic approach. Long Covid is a recent, poorly understood disease with several symptoms. Most recommendations suggest a multidisciplinary approach.Odette Linda Kamdem, Caroline Dupre, Valdez Heugno, Amandine Baudot, Estelle Essangui, Marie Blanquet, Nina Guercon, Marie Fanget, Sasha Bayet, Marie Pierre Vericel, Pauline Oustric, Yves Mbama Biloa , Elie Shikitele Lola, Mabrouk Nekaa, Mario Debellis, François Stierlam, Ronelle Fabiola Mbia, Olivier Tatsilong, Peguy Assomo Ndemba, Williams Bell Ngan, Valérie Ndobo, Clarisse Ayina Ayina, Jerson Mekoulou, Marie Solange Ndom Ebongue, Thomas Celarier, Louise Ruiz, Veronique Regnier, Claude Bika, Françoise Ngo Sack, Judith Laure Ngondi, Nathalie Barth, Samuel Honore Mandengue, Frederic Roche, Elisabeth Botelho-nevers, Carole Else Eboumbou Moukoko, Céline Nguefeu Nkenfou, David Hupin, Bienvenu Bongue, Jessica Guyot +38 moredoaj +2 more sources
