Results 111 to 120 of about 4,666,003 (287)

The Future of Research in Cognitive Robotics: Foundation Models or Developmental Cognitive Models?

open access: yesAdvanced Robotics Research, EarlyView.
Research in cognitive robotics founded on principles of developmental psychology and enactive cognitive science would yield what we seek in autonomous robots: the ability to perceive its environment, learn from experience, anticipate the outcome of events, act to pursue goals, and adapt to changing circumstances without resorting to training with ...
David Vernon
wiley   +1 more source

Convocando os hermeneutas da república iletrada: o prêmio Francisco Alves - Gathering the hermenauts of illiterate’s republic: the prize Francisco Alves

open access: yesHistória da Educação, 2014
Este artigo apresenta resultados de estudos e pesquisas centrados no Prêmio Francisco Alves, instituído pela Academia Brasileira de Letras sob a denominação de O melhor meio de disseminar o ensino primário no Brasil.
Carlos Roberto da Silva Monarcha, Brasil
doaj  

Deborah Olsen Public Service Scholarship Essay [PDF]

open access: yes, 2017
In this essay, Maura Hand reflects on the ten weeks she spent interning with the State Department\u27s Office of Foreign Missions (OFM) in San Francisco ...
Hand, Maura
core   +1 more source

RIG‐I Mediated Neuron‐Specific IFN Type 1 Signaling in FUS‐ALS Induces Neurodegeneration and Offers New Biomarker‐Driven Individualized Treatment Options for (FUS‐)ALS

open access: yesAdvanced Science, EarlyView.
Using iPSC‐derived motoneurons and postmortem tissue from FUS‐ALS patients, it is demonstrated that increased mitochondrial transcription leads to elevated cytosolic double‐stranded RNA (dsRNA) levels. This aberrant accumulation activates a RIG‐I–dependent innate immune response leading to neurodegeneration, which is amenable for FDA‐ and EMA‐approved ...
Marcel Naumann   +26 more
wiley   +1 more source

Allosteric Modulation of Pathological Ataxin‐3 Aggregation: A Path to Spinocerebellar Ataxia Type‐3 Therapies

open access: yesAdvanced Science, EarlyView.
This study uncovers a new allosteric site in the Josephin domain of ataxin‐3 targeted by the molecular tweezer CLR01, which modulates protein aggregation, improves synaptic function in neuronal cells, and delays motor dysfunction in animal models.
Alexandra Silva   +28 more
wiley   +1 more source

University Scholar Series: Kim Komenich [PDF]

open access: yes, 2012
Revolution Revisited On March 21, 2012, SJSU Assistant Professor Kim Komenich spoke in the University Scholar Series hosted by Provost Ellen Junn at the Dr. Martin Luther King, Jr. Library.
Komenich, Kim
core   +1 more source

Annexin A13 Protects Against Acute Kidney Injury by Inactivating TGF‐β/Smad3 Signaling

open access: yesAdvanced Science, EarlyView.
ANXA13 is negatively regulated by Smad3 and exerts its protective role in AKI by inactivating TGF‐β/Smad3 signaling and Smad3‐p21 cell cycle arrest pathway through binding to TβRI, inhibiting the interaction between TβRI and TβRII, thereby suppressing TβRI phosporylation.
Jiaxiao Li   +12 more
wiley   +1 more source

Platelet Rubicon Bidirectional Regulation of GPVI and Integrin αIIbβ3 Signaling Mitigates Stroke Infarction Without Compromising Hemostasis

open access: yesAdvanced Science, EarlyView.
This study identifies Rubicon as a key platelet protein that bidirectionally regulates GPVI and integrin αIIbβ3 signaling. Platelet Rubicon protects against cerebral ischemia‐reperfusion injury by limiting infarction without increasing hemorrhage.
Xiaoyan Chen   +11 more
wiley   +1 more source

Dungeness crab research program; Report for the year 1977 [PDF]

open access: yes, 1977
All 1977 year class larval stages, except fifth zoeae, occurred in the study area. California Cooperative Oceanic Fisheries Investigations (CalCOFI) plankton samples of February 1950, taken 67 and 111 miles off San Francisco, contained fifth stage ...

core  

Neural Circuits between Nodose Ganglion and Pulmonary Neuroendocrine Cells Regulate Lung Inflammatory Responses

open access: yesAdvanced Science, EarlyView.
TRPA1+αCGRP+ sensory neurons in the nodose ganglion detect external insults such as lipopolysaccharide (LPS) and interact directly with pulmonary neuroendocrine cells (PNECs), promoting their activation and proliferation. This neural‐epithelial interaction amplifies lung inflammation.
Jie Chen   +16 more
wiley   +1 more source

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