Prevalence of the Frank's sign by aetiopathogenic stroke subtype: A prospective analysis. [PDF]
PLoS ONE, 2021 Background and purposeThe Frank's sign is a diagonal earlobe crease running from the tragus to the edge of the auricle at an angle of 45°. Many studies have associated this sign with coronary artery disease and some with cerebrovascular disease.
Laura Sánchez-Cirera +7 more
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Association of Diagonal Earlobe Crease (Frank’s Sign) with Intracranial Aneurysm Rupture at Small Sizes [PDF]
Brain SciencesBackground: The diagonal earlobe crease (DELC), or Frank’s sign, has been associated with systemic vascular degeneration. Whether this cutaneous marker correlates with intracranial aneurysm (IA) instability remains unclear.
Joel Abraham Velazquez-Castillo +8 more
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Advancements in Frank’s sign Identification using deep learning on 3D brain MRI [PDF]
Scientific ReportsFrank’s sign (FS) is a diagnostic marker associated with aging and various health conditions. Despite its clinical significance, there lacks a standardized method for its identification.
Sungman Jo +10 more
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Diagonal Earlobe Crease and the Risk of New-Onset Atrial Fibrillation After Cavotricuspid Isthmus Ablation in Patients with Typical Atrial Flutter [PDF]
LifeBackground: Atrial fibrillation (AF) frequently develops in patients with atrial flutter (AFL), even after successful cavotricuspid isthmus (CTI) ablation. Identifying simple clinical markers for early detection is crucial. Diagonal earlobe crease (ELC),
Moo-Nyun Jin, Young Ju Kim, Changho Song
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Frank’s sign in anesthesia [PDF]
Anaesthesiology Intensive Therapy, 2020 Abdelghafour Elkoundi +3 more
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Frank's sign: a potential predictor of cardiovascular disease [PDF]
Journal of Community Hospital Internal Medicine Perspectives, 2015 Shoaib Bilal Fareedy +3 more
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Relationship between diagonal earlobe crease (Frank’s sign) and international index of erectile dysfunction score (IIEF-5) [PDF]
Journal of Men's Health, 2023 The objective of this study is to examine the association between erectile dysfunction (ED) and the presence of diagonal earlobe crease (DELC), a physical sign commonly associated with atherosclerosis.
Ugur Taylan Bilgilisoy
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Frank's sign with acute aortic dissection
Clinical Case Reports, 2022 A 59‐year‐old man with a long smoking history presented with sudden back pain. Frank's sign was noticed in his bilateral ears, and computed tomography revealed Stanford type A acute aortic dissection. If young patients have Frank's sign, attention should
Hironobu Nishiori +3 more
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Journal of Traditional Chinese Medical Sciences, 2023 Objective: To explore the value of ear morphological inspection in identifying the nine constitutions of traditional Chinese medicine (TCM) by analyzing the correlation between these two research objects.
Haotian Xie +9 more
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The importance of inspection in clinical cardiology: Frank's sign
Clinical Case Reports, 2022 The Frank's sign (FS) is a diagonal earlobe crease running from the tragus to the edge of the auricle. In this case, we describe a 71 years‐old male patient with FS who presented to the emergency department complaining of epigastric pain.
George Bazoukis +3 more
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