Results 31 to 40 of about 1,323,976 (332)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Regularity of the free boundary in the one-phase Stefan problem: a recent approach

Bruno Pini Mathematical Analysis Seminar, 2022
In this note, we discuss about the regularity of the free boundary for the solutions of the one-phase Stefan problem. We start by recalling the classical results achieved by I. Athanasopoulos, L. Caffarelli, and S.
Nicolò Forcillo
doaj   +1 more source

A parabolic free boundary problem with Bernoulli type condition on the free boundary [PDF]

, 2006
Consider the parabolic free boundary problem $$ \Delta u - \partial_t u = 0 \textrm{in} \{u>0\}, |\nabla u|=1 \textrm{on} \partial\{u>0\} . $$ For a realistic class of solutions, containing for example {\em all} limits of the singular perturbation ...
Georg, Georg S, H. W Alt, John Andersson, John Weiss, L. A. Caffarelli, S. Weiss   +6 more
core   +2 more sources

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Free boundaries in problems with hysteresis [PDF]

Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, 2015
Here, we present a survey concerning parabolic free boundary problems involving a discontinuous hysteresis operator. Such problems describe biological and chemical processes ‘with memory’ in which various substances interact according to hysteresis law.
D. E. Apushkinskaya, N. N. Uraltseva
openaire   +3 more sources

Free boundary problems involving singular weights [PDF]

Communications in Partial Differential Equations, 2020
In this paper we initiate the investigation of free boundary minimization problems ruled by general singular operators with $A_2$ weights. We show existence and boundedness of minimizers. The key novelty is a sharp $C^{1+ }$ regularity result for solutions at their singular free boundary points. We also show a corresponding non-degeneracy estimate.
Lamboley, Jimmy, Sire, Yannick, Teixeira, Eduardo   +2 more
openaire   +3 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Multidimensional transonic shock waves and free boundary problems

Bulletin of Mathematical Sciences, 2022
We are concerned with free boundary problems arising from the analysis of multidimensional transonic shock waves for the Euler equations in compressible fluid dynamics.
Gui-Qiang G. Chen, Mikhail Feldman
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

On the smoothness of the free boundary in a nonlocal one-dimensional parabolic free boundary value problem

Open Mathematics, 2015
We consider one-dimensional parabolic free boundary value problem with a nonlocal (integro-differential) condition on the free boundary. Results on Cm-smoothness of the free boundary are obtained.
Semerdjieva Rossitza
doaj   +1 more source