Results 51 to 60 of about 9,643,615 (243)
Is the free-energy principle neurocentric? [PDF]
Nature Reviews Neuroscience, 2010 Recently, a free-energy formulation of brain function was reviewed in relation to several other neurobiological theories (The freeenergy principle: a unified brain theory? Nature Rev. Neurosci. 11, 127–138 (2010))1. Fiorillo raises some interesting questions about the formulation from a neurocentric perspective (A neurocentric approach to Bayesian ...
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Predictive coding under the free-energy principle [PDF]
Philosophical Transactions of the Royal Society B: Biological Sciences, 2009 This paper considers prediction and perceptual categorization as an inference problem that is solved by the brain. We assume that the brain models the world as a hierarchy or cascade of dynamical systems that encode causal structure in the sensorium. Perception is equated with the optimization or inversion of these internal models, to explain sensory ...
Friston, K., Kiebel, S.
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Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Knowing one's place: a free-energy approach to pattern regulation. [PDF]
, 2015 Understanding how organisms establish their form during embryogenesis and regeneration represents a major knowledge gap in biological pattern formation.
Levin, M +3 more
core
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Free-Energy-Based Gene Mutation Detection Using LNA Probes
, 2019 We have developed a label-free approach for direct detection of gene mutations using free-energy values that are derived from single-molecule force spectroscopy (SMFS)-based nucleic acid unbinding experiments.
Siddhartha Banerjee (1902061) +2 more
core +1 more source
A Neural Network Implementation for Free Energy Principle
CoRR, 2023 12 pages, 3 figures, submitted to the 4th international workshop on active ...
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Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Frontiers in Psychology, 2022 Osteopathy is a person-centred healthcare discipline that emphasizes the body’s structure-function interrelationship—and its self-regulatory mechanisms—to inform a whole-person approach to health and wellbeing.
Jorge E. Esteves +5 more
doaj +1 more source
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source