Results 111 to 120 of about 2,624,763 (275)

Control of Space-Based Electron Beam Free Form Fabrication [PDF]

, 2007
Engineering a closed-loop control system for an electron beam welder for space-based additive manufacturing is challenging. For earth and space based applications, components must work in a vacuum and optical components become occluded with metal vapor ...
Seifzer. W. J., Taminger, K. M.
core   +1 more source

Ask Me Anything: Free-form Visual Question Answering Based on Knowledge from External Sources

, 2016
We propose a method for visual question answering which combines an internal representation of the content of an image with information extracted from a general knowledge base to answer a broad range of image-based questions.
Dick, Anthony, Hengel, Anton van den, Shen, Chunhua, Wang, Peng, Wu, Qi   +4 more
core   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

ASPECTS REGARDING THE OPTIMUM CUTTING TOOL PATH IN PROCESSING FREE-FORM [PDF]

Annals: Series on engineering sciences (Academy of Romanian Scientists), 2014
This paper describes an approach on tool paths optimization in CAM-type software for milling free forms, with the goal to improve efficiency in processing using CNC machine tools.
Florin CHIFAN, Cătălin Gabriel DUMITRAȘ, Gheorghe PLEȘU, Bogdan ANITA   +3 more
doaj  

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Superior bioavailability of the calcium salt form of β-hydroxy-β-methylbutyrate compared with the free acid form

Amino Acids
We investigated the bioavailability of the calcium salt (HMB-Ca) and the free acid (HMB-FA) forms of β-hydroxy-β-methylbutyrate (HMB). Sixteen young individuals received the following treatments on three different occasions in a counterbalanced crossover
Heitor Rodrigues Ribeiro, Felipe Gregório Jardim, Miriam Sanz Roldán, Vitor de Salles Painelli, Vinicius da Eira Silva, Aline Cristina Capparelli Tritto, Andressa Formalioni, Giovani Boldrini Custoias, Wagner Ribeiro Pereira, Marina Yazigi Solis, Felipe Carvalho, Ernani Pinto Junior, Guilherme Giannini Artioli   +12 more
doaj   +1 more source