Results 141 to 150 of about 2,624,763 (275)

Leveraging Free-Form Comments to Assess and Improve Patient Satisfaction. [PDF]

Ann Fam Med, 2022
Terpend R, Rossetti C, Kroes J, Mudge S, Glass J.   +4 more
europepmc   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Overall study of solar simulation optical system with large irradiated surface using free-form concentrator to improve uniformity. [PDF]

iScience, 2023
Liu S, Zhang J, Zhang Y, Zhang S, Yang S, Zou G, Liu L.   +6 more
europepmc   +1 more source

Portable Electron-Beam Free-Form Fabrication System [PDF]

A portable electron-beam free-form fabrication (EB F3) system, now undergoing development, is intended to afford a capability for manufacturing metal parts in nearly net sizes and shapes.
Hafley, Robert A., Petersen, Daniel D., Taminger, Karen M., Watson, J. Kevin   +3 more
core   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

A Novel Approach for Measurement of Free-Form Optical Elements with Digital Holographic Microscopy. [PDF]

Micromachines (Basel), 2022
Zhang X, Wu C, Chen L, Chen G, Zheng G.
europepmc   +1 more source

Free Form Volumes

, 1994
Free form volumes in rational Bézier representation are defined via homogeneous coordinates and two applications are pointed out : generation of solid primitives and curve and surface modelling by the way of volume deformation. Visualization techniques are reviewed, too.
openaire   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

GEOMETRY AND COMPLEXITY IN ARCHITECTURE

Journal of Industrial Design and Engineering Graphics, 2015
As Constantin Brancuși (1876-1956) said „Simplicity is complexity itself“, simplicity and regularity through the use of basic geometric forms has always played a central role in architectural design, during the 20th century.
RUSU Maria Ana
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