Results 231 to 240 of about 3,369,323 (272)

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Progressive Development of a New Tool for Rapid Thematic Analysis of Community Perceptions and Concerns During Health Emergencies. [PDF]

Glob Health Sci Pract
Earle-Richardson G, Nestor C, Prue CE.
europepmc   +1 more source

Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham, Sahana Sathyanarayana, Charlotte B. Stewart, Robyn Iredale, Victoria Foster, Debra Galley, Mark Baker, Nicola Pavese   +7 more
wiley   +1 more source

Real‐World Investigation of Satralizumab in Patients With Neuromyelitis Optica Spectrum Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Satralizumab, a monoclonal antibody targeting the interleukin‐6 receptor, has demonstrated efficacy in clinical trials for neuromyelitis optica spectrum disorder (NMOSD). However, its real‐world effectiveness and safety compared to conventional immunosuppressive therapies remain uncertain.
Li‐Tsung Lin, Hui‐An Lin, Sheng‐Feng Lin   +2 more
wiley   +1 more source

Defluoroalkylation of Trifluoromethane with Organolithium Reagents: Mechanism and Synthesis of Fluoroalkenes. [PDF]

Angew Chem Int Ed Engl
Warsame HR, Patrick SL, Bull JA, Miller PW, Crimmin MR.   +4 more
europepmc   +1 more source

Biocatalytic 3D binary crystals formed through the self-assembly of enzyme-embedded ferritin.

Nanoscale
Zhou Y, Rosenlöf L, Shen B, Kostiainen MA.   +3 more
europepmc   +1 more source

Cognitive maps for hierarchical spaces in the human brain. [PDF]

Cereb Cortex
Peer M, Epstein RA.
europepmc   +1 more source

Selective Activation of Dynamics in Kinetically Frozen Supramolecular Polymer Bottlebrush Assemblies. [PDF]

Small
Ulrich HF, Klein T, Zhao Z, Cseresnyés Z, Carravilla P, Gerst R, Kasberg A, Scharfenberg FP, Figge MT, Eggeling C, Brendel JC.   +10 more
europepmc   +1 more source

Predicting the Stability of Base-mediated C─H Carboxylation Adducts Using Data Science Tools. [PDF]

Angew Chem Int Ed Engl
Eckhoff M, Deolka S, Garcia-Roca A, Meynberg L, Seidel L, Sigman MS, Proppe J.   +6 more
europepmc   +1 more source