Results 131 to 140 of about 1,037 (170)

SDPR–STK38 axis controls the proliferation–differentiation balance in alveolar type II cells

Animal Models and Experimental Medicine, EarlyView.
The present study identifies SDPR as a pivotal regulator orchestrating the balance between proliferation and differentiation in alveolar type II (AT2) cells. In SDPR+/+ cells, SDPR binds to and inhibits STK38 activity, thereby sustaining GSK‐3β signaling functionality to promote cyclin D1 degradation and maintain cell cycle homeostasis.
Jie Wang, Xuepei Lei, Yiying Huang, Jiaming Tang, Guiying Shi, Hang Li, Lin Bai   +6 more
wiley   +1 more source

Tet Transgene Activation is Disrupted in Lipogenic Triple Negative Breast Cancer Cells. [PDF]

ACS Synth Biol
Townsel A, Wu Y, Jaffe M, Shields C, Haynes KA.   +4 more
europepmc   +1 more source

Stem cell–based therapies for type 1 diabetes: Progress in differentiation, clinical translation, and immune protection

Animal Models and Experimental Medicine, EarlyView.
Directed differentiation of pluripotent stem cells into functional pancreatic β cells have emerged as a promising strategy for the radical treatment of type 1 diabetes, with preclinical and early clinical evidence demonstrating reversal of hyperglycemia and insulin independence.
Zifan Li, Yu Kang, Yuyu Niu
wiley   +1 more source

In vitro and in vivo modeling systems of supratentorial ependymomas. [PDF]

Front Oncol
Hatanaka EA, Breunig JJ.
europepmc   +1 more source

Humanized immune system animal models and their recent applications

Animal Models and Experimental Medicine, EarlyView.
In this review, we provide an updated and comprehensive overview of the current state of humanized immune system animal model research. We discuss the variety of techniques used to produce humanized mice with their respective strengths and weaknesses, and evaluate the advantages and limitations of these models, including issues with incomplete immune ...
Nicolas Skuli, Rudra B. Amin, A’ishah Bakayoko, Marisa Kruidenier, Sahara Aqui, Sarah J. Skuli, Terence P. Gade   +6 more
wiley   +1 more source

Gingival Zenith Correction by Laser Gingivectomy. [PDF]

Cureus
Mohan S, Lavu V.
europepmc   +1 more source

Recent advances in the construction of humanized animal models and applications in translational medicine

Animal Models and Experimental Medicine, EarlyView.
Substantial advances have been achieved in the development of humanized mouse models, which have proven highly valuable in evaluating cancer immunotherapies and elucidating the mechanisms of infectious diseases. There is now a growing shift in research toward larger animal models—such as pigs—that offer greater physiological similarity to humans ...
Yanan Lyu, Yong‐Guang Yang, Zheng Hu
wiley   +1 more source

Exploring the anti-quorum sensing potential of synthetic lipstick dyes against <i>Pseudomonas</i> <i>aeruginosa</i>. [PDF]

New Microbes New Infect
Narayanasamy A, Kanagaraja A, Dhanabalan AK, Sudhakaran P, Thirumavalavan M, Velusamy P, Anbu P, Raman P.   +7 more
europepmc   +1 more source

Identification of senescence‐related genes in Parkinson's disease reveals candidate therapeutic targets and pathological processes

Animal Models and Experimental Medicine, EarlyView.
At the genomic level, a large number of differentially expressed genes (DEGs) and aging‐related DEGs have been screened. Ten hub genes, such as IFNγ and IRF7, have been identified and shown potential value in the diagnosis of PD, holding promise as novel biomarkers to facilitate early and precise diagnosis.
Haojie Wu, Tingting Liu, Xiangshu Cheng, Jianshe Wei   +3 more
wiley   +1 more source

TAF15 in tumor-associated macrophages enhances protumorigenic polarization and promotes cholangiocarcinoma progression. [PDF]

JHEP Rep
Liu Y, Xu B, Zhao T, Liu H, Pan Y, Zhao S, Chen Q, Wang L, Bai G, Zhang N, Zhou Y, Wei J, Fu X, Zhou Y, Wang Z, Xu L, Zhu Y, Shen S, Yang S, Zhou L, Wang L.   +20 more
europepmc   +1 more source