Results 71 to 80 of about 12,490 (212)
Tracking the Evolution of the Companionate Marriage Ideal in Early Modern Comedies [PDF]
, 2018 This thesis examines the socially constructed ideal of companionate marriage in Elizabethan and Jacobean England through four dramas by Christopher Marlowe, William Shakespeare, John Fletcher, Thomas Dekker and Thomas Middleton. It probes the question of
Pierce, Madison L
core +2 more sources
Advanced Science, EarlyView.HSP90α is significantly upregulated in platelets from sepsis patients, with its origin from megakaryocyte‐derived trafficking. Furthermore, activated platelets secrete HSP90α into the extracellular space in both free and exosome‐associated forms. Finally, extracellular HSP90α directly engages TLR4 on neutrophils to induce autophagy, leading to NET ...
Chengbo Wang +17 more
wiley +1 more source
A Tac1‐Expressing Brainstem Pathway Underlies the Pathogenesis of Trigeminal Neuralgia
Advanced Science, EarlyView.A critical TG‐Sp5CTac1‐PBNTac1 pathway drives trigeminal neuropathic pain (TNP). Tac1‐expressing parabrachial nucleus (PBNTac1) neurons exhibit heightened responses to innocuous stimuli in TNP, and chemogenetic inhibition of these neurons effectively prevents TNP development.
Liting Sun +11 more
wiley +1 more source
Advanced Science, EarlyView.We identify a Lepidoptera‐conserved testis‐specific arylalkylamine N‐acetyltransferase (LTNAT) that governs male moth fertility via a novel mechanism. LTNAT loss disrupts eupyrene sperm mitochondrial derivatives and impairs apyrene sperm motility, offering a safe molecular target for innovative pesticides and genetic pest control.
Hao Sun +5 more
wiley +1 more source
Advanced Science, EarlyView.Advanced clear cell renal cell carcinoma metastasis is driven by a FOXC2+ tumor subpopulation. These cells execute vasculogenic mimicry for dissemination and secrete LAMA4. LAMA4 engages macrophage ITGA6, activating the STAT6/GATA3 axis to polarize macrophages into a pro‐metastatic, immunosuppressive phenotype.
Jiaxi Yao +11 more
wiley +1 more source
In the Beginning Was the Verb: The Emergence and Evolution of Language Problem in the Light of the Big Bang Epistemological Paradigm. [PDF]
, 2008 The enigma of the Emergence of Natural Languages, coupled or not with the closely related problem of their Evolution is perceived today as one of the most important scientific problems.
Belaga, Dr. Edward G.
core
The Regulatory Role of Iron Transporter SLC39A13 in Liver Fibrosis
Advanced Science, EarlyView.SLC39A13/ZIP13, a newly discovered intracellular iron transporter, delivers iron to the ER/Golgi to catalyze procollagen hydroxylation during collagen maturation. Here, we systematically characterize the cell type‐specific functions of ZIP13 across distinct hepatic cell populations, and identify hepatic stellate cell‐specific ZIP13 as a promising and ...
Shanshan Guo +5 more
wiley +1 more source
Novel suspension retroviral packaging cells generated by transposition using transposase encoding mRNA advance vector yields and enable production in bioreactors. [PDF]
Front Bioeng Biotechnol, 2023 van Heuvel Y +7 more
europepmc +1 more source
Advanced Science, EarlyView.The diagram depicts the endothelial‐protective mechanism of magnesium lithospermate B (MLB) in sepsis‐associated lung injury. MLB binds GPX4 at Gly79, disrupts its interaction with FUNDC1, prevents mitophagy‐mediated GPX4 degradation, restores mitophagic flux, reduces ROS, and limits ferroptosis.
Zhixi Li +10 more
wiley +1 more source
Advanced Science, EarlyView.The oral bacterium Streptococcus salivarius promotes colorectal cancer metastasis by inducing neutrophil extracellular trap (NET) formation. Mechanistically, IRGM1–IQGAP1 interaction activates Wnt5a–PI3K/AKT signaling in neutrophils, driving NET‐mediated tumor progression.
Fengyi Liu +13 more
wiley +1 more source