Results 31 to 40 of about 89,092 (266)
ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
A free boundary seepage problem through earth dam withan impermeable screen
Известия высших учебных заведений: Проблемы энергетики, 2017 A water seepage problem through the rectangular earth dam with the presence of a vertical impermeable screen was studied in nonlinear formulation. A finite-difference scheme with a fixed mesh was used for discretization of mathematical equations with a ...
K. P. Kurtseva +2 more
doaj +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
International Journal of Applied Mechanics and Engineering, 2015 In the paper the influence function and the method of partial discretization in free axisymmetric vibration analysis of multilayered circular plates of constant and linearly variable thickness were presented.
K.K. Żur, J. Jaroszewicz, Ł. Dragun
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FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
On a variational principle for shape optimization and elliptic free boundary problems
Revista de Matemática: Teoría y Aplicaciones, 2009 A variational principle for several free boundary value problems using a relaxation approach is presented. The relaxed Energy functional is concave and it is defined on a convex set, so that the minimizing points are characteristic functions of sets.
Raúl B. González De Paz
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Protocol for quantifying miRNA trafficking across the endosomal membrane
FEBS Open Bio, EarlyView.An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh +2 more
wiley +1 more source
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
Stability of Solutions to a Free Boundary Problem for Tumor Growth
International Journal of Differential Equations, 2014 We study the asymptotic behaviour of quasi-stationary solutions of a free boundary problem which had been discussed by Bueno (2005). Using a simpler method we prove that the quasi-steady solutions of the problem converge uniformly to the unique ...
Shihe Xu
doaj +1 more source