Results 81 to 90 of about 1,439,807 (264)

Copyright and free culture

, 2005
Jason Griffey, The Perils of Strong Copyright: The American Library Association and Free Culture, a Master's Thesis at the University of North Carolina at Chapel Hill, 2004 (but newly deposited in the dLIST repository). Abstract: 'The current state of intellectual property law is labyrinthine in every sense: it is difficult to follow,
openaire   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Single‐Use, Metabolite Absorbing, Resonant Transducer (SMART) Culture Vessels for Label‐Free, Continuous Cell Culture Progression Monitoring

Advanced Science
Secreted metabolites are an important class of bio‐process analytical technology (PAT) targets that can correlate to cell conditions. However, current strategies for measuring metabolites are limited to discrete measurements, resulting in limited ...
Yee Jher Chan, Dhananjay Dileep, Samuel M. Rothstein, Eric W. Cochran, Nigel F. Reuel   +4 more
doaj   +1 more source

Adhesion and proliferation behavior of primary human mesenchymal stem cells on sulfated cellulose nanofiber scaffolds with different sulfate contents

Carbohydrate Polymer Technologies and Applications
Primary human mesenchymal stem cells (hMSCs) have attracted much attention in regenerative medicine, where stem cell culture currently requires xeno-free (xenogeneic component-free) systems for both media and scaffolds.
Ritomo Kai, Mayumi Hatakeyama, Shinichiro Iwamoto, Takuya Kitaoka   +3 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Maltose metabolism in serum free CHO culture involves lysosomal acid α-glucosidase

Scientific Reports
Mammalian cells have been previously shown to utilize maltose as an energy source for long-term cell growth. To characterize maltose uptake and consumption in CHO-K1, we measured its intracellular concentrations over time and tracked the incorporation of
Tessa Rui Min Tan, Lian Yee Yip, Janice Gek Ling Tan, Dawn Sow Zong Leong, Yan Ni Annie Soh, Shi Ya Mak, Ying Swan Ho, Say Kong Ng   +7 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Pseudomonas protegens ML15 and Trichoderma koningiopsis Tr21 co-culture: A potent strategy for suppressing Fusarium cerealis infections in wheat through augmented antifungal metabolite production

Biological Control
Wheat (Triticum aestivum L.), a staple grain consumed worldwide, is heavily affected by Fusarium species, which cause harmful diseases that threaten its production. The present study was conducted to investigate the biocontrol activity of monocultures of
Nur Ajijah, Angelika Fiodor, Krzysztof Kazimierczuk, Monika Urbaniak, Elsie Enow, Robert Stasiuk, Lukasz Stepien, Lukasz Dziewit, Kumar Pranaw   +8 more
doaj   +1 more source