Results 101 to 110 of about 480 (252)

FGF13 Deficiency Ameliorates Paclitaxel‐Induced Neuropathic Pain by Inhibiting VASH1‐Mediated Microtubule Detyrosination to Promote Mitophagy

Advanced Science, EarlyView.
FGF13 is upregulated in DRG neurons of PIPNP model mice. DRG neuron‐specific knockout of FGF13 ameliorates PIPNP symptoms. Mechanistically, FGF13 potentiates microtubule detyrosination by promoting VASH1 binding to microtubules. FGF13 knockout suppresses VASH1‐mediated microtubule detyrosination and promotes α‐tubulin tyrosination.
Yiming Dong, Yidan Wang, Simeng Lv, Zishan Dong, Kaixi Zhi, Xiuhua Guo, Xuyan Li, Ruoxi Yu, Yiyi Zhang, Siyuan Cheng, Chuan Wang   +10 more
wiley   +1 more source

Occurrence Rates of Exosatellites Orbiting 3–30 M Jup Hosts from 44 Spitzer Light Curves

The Astronomical Journal
We conduct a comprehensive search for transiting exomoons and exosatellites within 44 archival Spitzer light curves of 32 substellar worlds with estimated masses ranging between 3 and 30 M _Jup . This sample’s median host mass is 16 M _Jup , inclusive of
Mary Anne Limbach, Johanna M. Vos, Andrew Vanderburg, Fei Dai   +3 more
doaj   +1 more source

Targeting Supramolecular Active Complexes of Nav1.7/Nav1.8 to Relieve Chronic Neuropathic Pain

Advanced Science, EarlyView.
In mice and patients with severe chronic neuropathic pain (NP), Nav1.7, Nav1.8, TrkB, and five cytoskeletal proteins form supramolecular active complexes (SMACs) with polygonal lattice structures as noxious signal amplifiers in dorsal root ganglion (DRG) neurons.
Liting Sun, Hang Xian, Yunxin Shi, Taotan Yang, Hongyan Shuai, Wenchao Hu, Siying Fei, Miao Xu, Taoyuan Yang, Ruilong Xia, Ting Wen, Fengting Zhu, Yan Fu, Yang Li, Wei Xia, Ran Qian, Yuanying Liu, Zhicheng Tian, Lamei Li, Qian Zhou, Lize Xiong, Rui Cong, Ceng Luo, Shengxi Wu, Xiafeng Shen, Xin Yu, Rou‐Gang Xie, Changgeng Peng   +27 more
wiley   +1 more source

A Deep Search for Exomoons around WISE 0855 with JWST

The Astronomical Journal
The James Webb Space Telescope (JWST) is collecting time-series observations of many free-floating planets (FFPs) to study their weather, but these light curves provide ideal datasets for locating exomoons that transit FFPs during observations.
Mikayla J. Wilson, Mary Anne Limbach, Andrew J. Skemer, Johanna M. Vos, Brittany E. Miles, Melanie J. Rowland, Andrew Vanderburg, Adam C. Schneider, Caroline Morley, Brooke Kotten, Andrew Householder, Roxana Lupu, James Mang, Richard Freedman   +13 more
doaj   +1 more source

Dynamical evolution of massless particles in star clusters with NBODY6++GPU-MASSLESS

Astronomy & Astrophysics
Context. Comets, asteroids, planetesimals, free-floating planets, and brown dwarfs are continuously injected into the intracluster environment after expulsion from their host-planetary systems or binary system.
Flammini Dotti Francesco, Kouwenhoven Mattheus Bartholomeus Nicolaas, Wu Kai, Askar Abbas, Berczik Peter, Giersz Mirek, Spurzem Rainer, Dobbs-Dixon Ian   +7 more
doaj   +1 more source

Globulettes: Formation Sites Of Free Floating Planets?

, 2017
NIR imaging and ALMA arc-second resolution CO, CS and H2CO imaging of two typical Rosette Nebula globulettes is discussed. Velocity structure is observed in the 12CO line whereas the observed CS line widths are are extremely narrow, 0.3kms-1-0.4kms-1, indicating practically no internal motions in the very core.
openaire   +2 more sources

Enhancing Maturation of Human Neuromuscular Organoids via Electrical Stimulation

Advanced Science, EarlyView.
A framework for on‐demand and non‐invasive exposure of human neuromuscular organoids (NMOs) to electrical stimuli is established to promote their maturation. The robustness and effectiveness of different stimulation regimes are evaluated via thorough characterization of organoid tissue structure and contraction capacity. Chronic electrical stimulation,
Chrysanthi‐Maria Moysidou, Inês Afonso Martins, Ismail Amr El‐Shimy, Iacopo Bicci, Donatella Cea, Christina Bukas, Isra Mekki, Mara‐Camelia Rusu, Aylin Nebol, Ines Lahmann, Marie Piraud, Enrico Klotzsch, Mina Gouti   +12 more
wiley   +1 more source

ROS Self‐Supply Nanoplatform Based on Fenton Catalyst for Chemodynamic and Immunotherapy: Reprogramming Cold Tumor Into Hot Tumor in Cancer Treatment

Advanced Science, EarlyView.
A multifunctional HA‐conjugated nanoplatform (HA‐PGMC) integrates CuO2, glucose oxidase, and mil‐100 to enable cascade catalytic ROS generation in tumor microenvironments. This self‐supplying ROS strategy induces immunogenic cell death, reprograms “cold” tumors into “hot” ones, and synergizes with PD‐L1 blockade, achieving potent chemodynamic ...
Man Lung Lee, Jack Chun Hin Chen, Wai Wing Cheng, Kwan Yee Lau, Hiu Yee Kwan, Ngar‐Yun Ellen Poon, Hung‐Wing Li   +6 more
wiley   +1 more source

Free-floating planets: a viable option for panspermia

, 2010
Genomic complexity can be used as a clock with which the moment in which life originated can be measured. Some authors who have studied this problem have come to the conclusion that it is not possible that terrestrial life originated here and that, in reality, life originated giga-years ago, before the solar system existed. If we accept this conclusion
openaire   +2 more sources

Detectability of Free Floating Planets in Open Clusters with JWST

, 2013
Recent observations have shown the presence of extra-solar planets in Galactic open stellar clusters, as in the Praesepe (M44). These systems provide a favorable environment for planetary formation due to the high heavy-element content exhibited by the majority of their population. The large stellar density, and corresponding high close-encounter event
Pacucci, Fabio, Ferrara, Andrea, D'Onghia, Elena   +2 more
openaire   +2 more sources