Results 221 to 230 of about 9,681,538 (276)

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Selective Omission of Ureteral Access Sheath in Retrograde Intrarenal Surgery: Surgical and Safety Outcomes from a Single-Center Retrospective Cohort Study. [PDF]

J Clin Med
Liang PS, Chang YJ, Chen JK, Shih HJ.
europepmc   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

The value-added challenge of nuts: antioxidant components, functions and applications in nut by-products. [PDF]

Front Nutr
Zhou Y, Fan Y, Yang Z, Han X, Li Y, Liu T, Sun N, Chen T, Meng L.   +8 more
europepmc   +1 more source

Evaluating the effects of ultrasonic and high-pressure homogenization on the flavor profile of Wuliang Mountain black-boned chicken soup. [PDF]

Ultrason Sonochem
Jiang S, Chen H, Zhang S, Xu Z, Li S.
europepmc   +1 more source

Head and Neck Cutaneous Melanoma: Is Reduced Radial Margin of Excision Safe? [PDF]

Plast Surg (Oakv)
Clemente-Gutierrez U, Agarwal A, Buchko K, Seif-Elnasr M, Sayed S, Pathak KA.   +5 more
europepmc   +1 more source

Consumer credit evaluation model for free trade ports by a sparse attention transformer and graph neural network. [PDF]

Sci Rep
Wu M, Sabri MF, Meng C, Wang S.
europepmc   +1 more source

Development of Stearic Acid Nanoemulsion for Therapeutic Delivery of Talazoparib Against Breast Cancer. [PDF]

Pharmaceutics
Zhang J, Zhang Z, Xia X, Feng K, Yao S, Wang Y, Wu M.   +6 more
europepmc   +1 more source