Results 231 to 240 of about 7,845,575 (284)

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Experimental study on the coupling control of rock blasting vibration and rock fragmentation size. [PDF]

PLoS One
He L, Zhang W, Zhao Y, Peng S, Yao Y, Chen S, Wang M.   +6 more
europepmc   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Supporting migrant groups to reduce tobacco-related harms and create smoke-free family environments: Future priorities and research gaps

Tobacco Induced Diseases
Rachel O’Donnell, Olena Tigova, Piotr Teodorowski, Nazmy Villarroel-Williams, Anzhelika Shevchuk, Olena Nesterova, Yuliia Arabska, Alban Ylli, Gentiana Qirjako, Esteve Fernández, Sean Semple   +10 more
doaj   +1 more source

The role of reactivations during consolidation in the structure and accessibility of episodic autobiographical memories. [PDF]

Sci Rep
Lenormand D, Gaston-Bellegarde A, Orriols E, Piolino P.   +3 more
europepmc   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

Survival benefit and dynamics of CD8⁺ T cells and tumor-associated macrophages in neoadjuvant immunochemotherapy <i>vs</i>. chemotherapy for locally advanced esophageal squamous cell carcinoma: an IPTW-adjusted real-world study. [PDF]

Front Immunol
Gan Y, Li Y, Fang L, Chen Y, Yang D.
europepmc   +1 more source

Chitosan nanoparticle encapsulated pentoxifylline improves renal protection and reduces oxidative stress in amikacin induced nephrotoxicity. [PDF]

Discov Nano
Moustafa N, Abd El-Latif MB, Farid A.
europepmc   +1 more source