Results 71 to 80 of about 272,703 (311)
Foucault and Sedgwick: The Repressive Hypothesis Revisited
Foucault Studies, 2012 This essay examines the Foucauldian foundations of queer theory in the work of Eve Kosofsky Sedgwick. The essay argues that Sedgwick’s increasing disappointment with Foucault’s critique of the repressive hypothesis is in part produced by the slippery ...
Lynne Huffer
doaj +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Understanding Focus: Pitch, Placement and Coherence [PDF]
, 2020 This paper presents a novel account of focal stress and pitch contour in English dialogue. We argue that one should analyse and treat focus and pitch contour jointly, since (i) some pragmatic interpretations vary with contour (e.g., whether an utterance ...
Lascarides, Alex, Schlöder, Julian J.
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Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
No Accounting for Culture? Value in the New Economy [PDF]
, 2007 This paper explores the articulation of the value of investment in culture and the arts through a critical discourse analysis of policy documents, reports and commentary since 1997.
Boehm, Steffen, Land, Christopher
core
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Free indirect discourse in newspaper reports
Linguistics in the Netherlands, 1996 It has recently been noted (Onrust 1994) that two journalists at the Dutch daily newspaper NRC Handelsblad have introduced a new style of reporting on soccer and other ball games. Their articles present a mix of factual reporting of events, background information, interviews and commentary, employing a variety of literary techniques.
openaire +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Debatable discourse of phraseology: manipulations and linguistic games
Lietuvių Kalba, 2008 The paper discusses a debatable discourse of phraseology, both written and spoken, and analyses texts of different genres of public discourse. More attention is devoted to the semantic structure of idiomatic expressions and their modifications, i.e ...
Regina Koženiauskienė
doaj +1 more source
Germany’s agri-biotechnology policy [PDF]
, 2005 In Germany, the precautionary principle (PP) is a well-established legal principle in environmental law, especially for regulating agribiotechnology. This article uses the analytical concept of issue-framing to identify different views of the PP and how ...
Boschert, Karin, Gill, Bernhard
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