Results 81 to 90 of about 272,703 (311)
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
O Cadáver, um emblema da morte em “Ápeiron”, de Caio Fernando Abreu
Revista Criação & Crítica, 2010 The aim of the present article is to investigate the procedures used by Caio Fernando Abreu to construct the representations of death in his work. For this, I take, here, the short-story “Apeiron”, published in the book Inventário do irremediável (1970).
André Luiz Gomes de Jesus
doaj +1 more source
Language shifts in free indirect discourse
Journal of Literary Semantics, 2014 Abstract Free indirect discourse is a way of reporting what a protagonist thinks or says that is distinct from both direct and indirect discourse. In particular, while pronouns and tenses are presented from the narrator's perspective, as in indirect discourse, other indexical and expressive elements reflect the protagonist's point of ...
openaire +2 more sources
Quotation and Unquotation in Free Indirect Discourse [PDF]
Mind & Language, 2015 AbstractI argue that free indirect discourse should be analyzed as a species of direct discourse rather than indirect discourse. More specifically, I argue against the emerging consensus among semanticists, who analyze it in terms of context shifting.
openaire +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
American and British Studies Annual, 2010 By the time Katherine Mansfield started writing her stories, it had become almost a fashion to look down on Jane Austen and consider her work as dull or at the best outmoded.
Janka Kaščáková
doaj
Acta Neophilologica, 2007 Among the many unresolved issues in the field of translation studies is also the one pertaining to the question of who sees/speaks in the source and in the target text.
Uroš Mozetič
doaj +1 more source
Speech Acts: The Contemporary Theoretical Landscape [PDF]
, 2018 What makes it the case that an utterance constitutes an illocutionary act of a given kind? This is the central question of speech-act theory. Answers to it—i.e., theories of speech acts—have proliferated.
Fogal, Daniel +2 more
core
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source