Results 41 to 50 of about 5,138,290 (218)

Decoding Biomolecular Phase Separation: From Physiological Roles to Pathological Mechanisms and Therapeutic Biomaterials Design

Advanced Science, EarlyView.
This review systematically elaborates on the mechanisms underlying physiological regulation and pathological dysregulation of biomolecular phase separation. It also summarizes advances in phase‑separation‑targeted therapeutic strategies and the design of functional biomaterials inspired by this process.
Jiawei Zhu, Jingbo Dong, Qiufang Gong, Xuejiao Song, Zhifa Shen, Chao Liang   +5 more
wiley   +1 more source

Endocannabinoids Inhibit the Growth of Free-Living Amoebae [PDF]

Antimicrobial Agents and Chemotherapy, 2010
ABSTRACTThe cannabinoid Δ9-tetrahydrocannabinol inhibits the growth of some pathogenic amoebaein vitroand exacerbates amoebic encephalitis in animal models. However, the effects of endogenous cannabinoids on amoebae remain unknown. Therefore, we tested several endocannabinoids (N-acyl ethanolamines and 2-O-acyl glycerol) on different genera of amoebae.
Rafik, Dey, Pierre, Pernin, Jacques, Bodennec   +2 more
openaire   +2 more sources

Bridging the translational gap in clinical nanomedicine: From rational design to clinical reality

BMEMat, EarlyView.
Nanotechnology offers a multi‐faceted approach to modern healthcare, encompassing high‐sensitivity diagnostic imaging, innovative vaccine delivery, and targeted therapeutics. This review explores how these nanomedicine applications address critical challenges in cancer recurrence and the treatment of neurologic and respiratory diseases to combat rising
Ahmed H. Ghonaim, Marwa Ahmed El‐Naka, Wedad M. Nageeb, Atta Ullah Khan, Noura M. Seleem, Aliaa Abdelghafar, Doaa Zamel, Yang Liu, Qigai He, Wentao Li   +9 more
wiley   +1 more source

Investment centre manager's multiperiod fairness perceptions and intertemporal dependency

Accounting &Finance, Volume 65, Issue 1, Page 3-36, March 2025.
Abstract This paper explores the motivation of investment centre managers when their investment centre's performance is affected by decisions made by their predecessor. Through a qualitative case study of a Japanese manufacturer, the effectiveness of conventional remedies for motivational issues and further motivational issues caused by the same ...
Hiroyuki Selmes‐Suzuki
wiley   +1 more source

Cocultivation of Legionella pneumophila and free-living amoebae [PDF]

Applied and Environmental Microbiology, 1982
Studies of the interaction of Legionella pneumophila with free-living amoebae showed that Naegleria lovaniensis and Acanthamoeba royreba could use L. pneumophila as a sole food source. However, growth of the amoebae on nonnutrient agar plates seeded with L. pneumophila was slower than growth on nonnutrient agar plates seeded with Escherichia coli.
R L, Tyndall, E L, Domingue
openaire   +2 more sources

Population analysis of Legionella pneumophila reveals a basis for resistance to complement-mediated killing

Nature Communications, 2021
The bacterium Legionella pneumophila can cause severe respiratory infection, but is typically a symbiont of free-living amoeba. Here, the authors analyse the genomes of 902 clinical and environmental isolates, and identify a bacterial gene that is ...
Bryan A. Wee, Joana Alves, Diane S. J. Lindsay, Ann-Brit Klatt, Fiona A. Sargison, Ross L. Cameron, Amy Pickering, Jamie Gorzynski, Jukka Corander, Pekka Marttinen, Bastian Opitz, Andrew J. Smith, J. Ross Fitzgerald   +12 more
doaj   +1 more source

Outcomes of therapeutic penetrating keratoplasty and deep anterior lamellar keratoplasty in acanthamoeba keratitis: A systematic review and meta‐analysis

Acta Ophthalmologica, EarlyView.
Abstract While acanthamoeba keratitis (AK) is a sight‐threatening corneal infection, a thorough comparison of the outcomes of therapeutic penetrating keratoplasty (PK) and therapeutic deep anterior lamellar keratoplasty (DALK) is lacking. We aimed to compare clinical outcomes of PK and DALK in AK.
Gábor Tóth, Junbo Wang, Shanhe Liu, Shuailin Li, Szilárd Váncsa, Mátyás Paczkó, Tamás Kói, Péter Hegyi, Nóra Szentmáry   +8 more
wiley   +1 more source

Free-living protozoa in drinking water supplies: community composition and role as hosts for Legionella pneumophila [PDF]

, 2011
Free-living protozoa in drinking water supplies: community composition and role as hosts for Legionella pneumophila Free-living protozoa, which feed on bacteria, play an important role in the communities of microorganisms and invertebrates in drinking
Valster, R.M.
core  

Peranan Free Living Amoeba - Achantamoeba sebagai patogen penyebab kelainan pada otak dan mata [PDF]

, 2021
The free-living amoeba (FLA) group of protozoa that can be found in various types of conditions in nature, one of which is the genus Acanthamoeba. Although, the number of infections caused by this protozoan is low, the diagnosis was still difficult to ...
Sari, Ika Puspa, Halleyantoro, Ryan
core  

Evaluating the Presence of Free-Living Amoebae in Hostel Water Systems at a Tertiary Care Hospital: A Pilot Study

International Journal of Advanced Medical and Health Research
Background: Free-living amoebae (FLA) are environmental pathogens that can lead to skin infections and potentially life-threatening encephalitis in immunocompromised individuals.
Angel Anna Mathew, Sangitha Jayagandan, Rakesh Singh   +2 more
doaj   +1 more source