Results 31 to 40 of about 10,786,369 (336)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Conceptualisation of higher education: The neoliberal approach [PDF]

open access: yesNastava i Vaspitanje, 2019
Neoliberalism has become the dominant ideology of our time, impacting all segments of society. At the same time, higher education has been undergoing changes altering its identity, purpose, roles and position.
Đuković Anđela
doaj  

Fairness Is an Emergent Self-Organized Property of the Free Market for Labor

open access: yes, 2010
The excessive compensation packages of CEOs of U.S. corporations in recent years have brought to the foreground the issue of fairness in economics. The conventional wisdom is that the free market for labor, which determines the pay packages, cares only ...
Akerlof   +15 more
core   +3 more sources

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

open access: yesMolecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli   +7 more
wiley   +1 more source

România – o economie „planificată” de la distanţă (Romania – another kind of „planned” economy) [PDF]

open access: yesPolis: Revista de Stiinte Politice, 2015
Among all the Eastern European countries that joined the EU after 2000, Romania delayed for several years the economic reforms in order to ensure the transition to free market economy.
Ion-Lucian CATRINA
doaj  

ИДЕОЛОГИЧЕСКИЕ ОСНОВАНИЯ ЭКОЛОГИЧЕСКОЙ КУЛЬТУРЫ (НА ПРИМЕРЕ ЛИБЕРТАРИАНСТВА)

open access: yesSovremennye Issledovaniâ Socialʹnyh Problem, 2015
В статье на примере либертарианства производится анализ идеологических оснований экологической культуры. Задача статьи – реконструировать и систематизировать аргументы либертарианцев (Д. Бергланда, Д. Боуза, Дж.
Elena Grigorievna Kulagina   +1 more
doaj   +1 more source

Pricing Ad Slots with Consecutive Multi-unit Demand [PDF]

open access: yes, 2013
We consider the optimal pricing problem for a model of the rich media advertisement market, as well as other related applications. In this market, there are multiple buyers (advertisers), and items (slots) that are arranged in a line such as a banner on ...
Deng, Xiaotie   +4 more
core   +2 more sources

Higher Education between Government Policy and Free Market Forces: The Case of Israel

open access: yes, 2015
. In recent years Israel's system of higher education has undergone a revolutionary transformation, leading to a sharp rise in the number of students, establishment of new degree-granting institutions, and shifts in legislation and policy. All these have
Erez Cohen, N. Davidovitch
semanticscholar   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

open access: yesFEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies   +3 more
wiley   +1 more source

Free Market of Crowdsourcing: Incentive Mechanism Design for Mobile Sensing

open access: yesIEEE Transactions on Parallel and Distributed Systems, 2014
Off-the-shelf smartphones have boosted large scale participatory sensing applications as they are equipped with various functional sensors, possess powerful computation and communication capabilities, and proliferate at a breathtaking pace.
Xinglin Zhang   +5 more
semanticscholar   +1 more source

Home - About - Disclaimer - Privacy