Results 121 to 130 of about 8,660,418 (387)

Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer

open access: yesMolecular Oncology, EarlyView.
G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren   +16 more
wiley   +1 more source

Training vehicle for controlling attitude Patent [PDF]

open access: yes, 1966
Attitude control training device for astronauts permitting friction-free movement with five degrees of ...
Johnson, H. I.
core   +1 more source

Mechanical restriction versus human overreaction triggering congested traffic states

open access: yes, 2004
A new cellular automaton (CA) traffic model is presented. The focus is on mechanical restrictions of vehicles realized by limited acceleration and deceleration capabilities.
B. S. Kerner   +12 more
core   +1 more source

Comprehensive omics‐based classification system in adult patients with B‐cell acute lymphoblastic leukemia

open access: yesMolecular Oncology, EarlyView.
The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song   +11 more
wiley   +1 more source

Unity and Diversity in the European Union’s Internal Market Case Law: Towards Unity in ‘Good Governance’?

open access: yesUtrecht Journal of International and European Law, 2018
This article deals with an enduring challenge for the European Court of Justice: striking a balance between the EU market integration requirements and respecting the ‘fundamental structures’ that exist in the Member States through the recognition and ...
Jotte Mulder
doaj   +1 more source

Dose‐dependent induction of epithelial‐mesenchymal transition in 3D melanoma models by non‐thermal plasma treatment

open access: yesMolecular Oncology, EarlyView.
Non‐thermal plasma treatment of melanoma cells induced epithelial‐mesenchymal transition (EMT) in a dose‐dependent fashion. This report highlights the critical need to further investigate potential adverse effects of non‐thermal plasma for cancer therapy and to optimize treatment parameters for clinical translation. Despite the promising results of non‐
Eline Biscop   +10 more
wiley   +1 more source

The four freedoms in the EU: Are they inseparable? Bertelsmann Stiftung EUROPA Briefing 2017 [PDF]

open access: yes, 2017
The four freedoms govern the movement of goods, persons, services and capital within the EU. They are the cornerstones of the Single Market and the common currency.
auf dem Brinke, Anna
core  

Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma

open access: yesMolecular Oncology, EarlyView.
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias   +12 more
wiley   +1 more source

Free movement of services in the european union [PDF]

open access: yes
In 2004, Frits Bolkenstein, former European Commissioner for the Internal Market, brought in the attention of the European Commission “The Services Directive in the Internal Market”. The purpose of this directive was to liberalize the services’ market in
Rotaru, Marius-Petre
core   +1 more source

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