Results 121 to 130 of about 5,578,766 (311)
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
EU Social Security Law: A Commentary on EU Regulations 883/2004 and 987/2009
Administration, 2016 Mangan Gerry
doaj +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
The Free Speech Movement: reflections on Berkeley in the 1960s
, 2002 This is the authoritative and long-awaited volume on Berkeley's celebrated Free Speech Movement (FSM) of 1964. Drawing from the experiences of many movement veterans, this collection of scholarly articles and personal memoirs illuminates in fresh ways ...
University of California, Berkeley +5 more
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Revista Vasca de Administración Pública, 2009 The level of accomodation of linguistic justifi cations as values that might justify restriction to the Community freedoms and free competition has not found a good answer in European primary law.
Iñigo Urrutia Libarona
doaj +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Columbus Free Press subscription form
, 1990 Order form encouraging subscription to and financial support for the Columbus Free Press. It also announces that the newspaper will no longer be available for free, but can be obtained by subscription or for $1 per copy at Free Press newsboxes.
Columbus Free Press (Publisher)
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Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source