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Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
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Molecular Oncology, EarlyView.Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant +11 more
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Endogenous Timing with Free Entry [PDF]
SSRN Electronic Journal, 2006 A free entry model with linear costs is considered where firms first choose their entry time and then compete in the market according to the resulting timing decisions. Multiple equilibria arise allowing for infinitely many industry output configurations encompassing one limit-output dominant firm and the Cournot equilibrium with free entry as extreme ...
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JAMA, 1971
To the Editor.— The letter of Dr. Beychok ( 215 :2112, 1971) concerning a way to reduce the consumption of time by busy physicians struck a responsive chord and I think requires further discussion and consideration. I am sure that all physicians in practice feel that they spend an unnecessary amount of their time on paperwork which could be ...
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To the Editor.— The letter of Dr. Beychok ( 215 :2112, 1971) concerning a way to reduce the consumption of time by busy physicians struck a responsive chord and I think requires further discussion and consideration. I am sure that all physicians in practice feel that they spend an unnecessary amount of their time on paperwork which could be ...
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2016
Recent debates about inequality have focused almost exclusively on the distribution of wealth and disparities in income, but little notice has been paid to the distribution of free time. Free time is commonly assumed to be a matter of personal preference, a good that one chooses to have more or less of. Even if there is unequal access to free time, the
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Recent debates about inequality have focused almost exclusively on the distribution of wealth and disparities in income, but little notice has been paid to the distribution of free time. Free time is commonly assumed to be a matter of personal preference, a good that one chooses to have more or less of. Even if there is unequal access to free time, the
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TIME, FREE WILL, AND MODERN PHYSICS
2023To what extent can the way we represent the nature of time in physics influence our conception of human freedom? The difficulty of this question is that a precise answer is not possible without raising two further questions: what freedom are we talking about? What area of physics are we thinking about?
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2018
The term free time (like Italian tempo libero, Spanish tiempo libre, and German Freizeit; cf. American spare time) is defined etymologically as the opposite of “occupied time” or working hours. The “freedom” of time has positive connotations; it suggests voluntary, pleasant occupations and a historical process of liberation from social obligations and ...
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The term free time (like Italian tempo libero, Spanish tiempo libre, and German Freizeit; cf. American spare time) is defined etymologically as the opposite of “occupied time” or working hours. The “freedom” of time has positive connotations; it suggests voluntary, pleasant occupations and a historical process of liberation from social obligations and ...
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"Free" Time for the Practicing Physician
JAMA: The Journal of the American Medical Association, 1971To the Editor.— If it is intellectually granted that physicians need more time for the management of more sick people, does this support the use of medically trained assistants to "free" the physician to better utilize his special knowledge and talents? It would be more consistent to train secretaries capable of extracting information once recorded or
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