Results 1 to 10 of about 227,324 (219)

Discovery of SARS-CoV-2 main protease covalent inhibitors from a DNA-encoded library selection

SLAS Discovery, 2022
Covalent inhibitors targeting the main protease (Mpro, or 3CLpro) of SARS-CoV-2 have shown promise in preclinical investigations. Herein, we report the discovery of two new series of molecules that irreversibly bind to SARS-CoV-2 Mpro.
Rui Ge, Zuyuan Shen, Jian Yin, Wenhua Chen, Qi Zhang, Yulong An, Dewei Tang, Alexander L. Satz, Wenji Su, Letian Kuai   +9 more
doaj   +1 more source

Screening and early diagnosis of chronic obstructive pulmonary disease: a population study

BMC Pulmonary Medicine, 2023
Background and objective Although chronic obstructive pulmonary disease (COPD) is a common disease leading to further morbidity and significant mortality, there is still limited data on screening for COPD.
Wenhui Tang, Yan Rong, Hongmei Zhang, Wenji Lin, Wenmei Zeng, Wenhong Wu   +5 more
doaj   +1 more source

Research trends in the mental health and multimorbidity of older people from 2002 to 2022: A bibliometric analysis via CiteSpace

Frontiers in Psychiatry, 2023
PurposeUsing bibliometric analysis, the objective of this study was to identify research hotspots and trends on multimorbidity and mental health in older adults.
Jie Zhou, Dan Song, Juanjuan Ma, Guowen Zhang, Chuduo Wu, Qian Chen, Li Zeng   +6 more
doaj   +1 more source

A functional antibody cross-reactive to both human and murine cytotoxic T-lymphocyte-associated protein 4 via binding to an N-glycosylation epitope

mAbs, 2020
Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4, CD152) is a receptor on T cells that inhibits the cell’s functions. Blocking CTLA-4 with an antibody has proven effective for the treatment of cancer patients. Anti-CTLA-4 antibodies currently approved
Dong Li, Jing Li, Huanyu Chu, Zhuozhi Wang   +3 more
doaj   +1 more source

Urinary incontinence as a main clinical manifestation of early stage Wernicke’s encephalopathy: a case report

Frontiers in Neurology, 2023
Wernicke’s encephalopathy (WE) is a condition caused by a deficiency of vitamin B1. While there have been many reported cases of WE in the literature, there are few reports on the early stages of the disorder. In this report, we present a case of WE with
Haitian He, Kebing Wang, Kebing Wang, Yang Wang, Jinbin Luo   +4 more
doaj   +1 more source

Research on Neural Network Terminal Sliding Mode Control of Robotic Arms Based on Novel Reaching Law and Improved Salp Swarm Algorithm

Actuators, 2023
Modeling errors and external disturbances have significant impacts on the control accuracy of robotic arm trajectory tracking. To address this issue, this paper proposes a novel method, the neural network terminal sliding mode control (ALSSA-RBFTSM ...
Jianguo Duan, Hongzhi Zhang, Qinglei Zhang, Jiyun Qin   +3 more
doaj   +1 more source

A Cross-Sectional Study of Depression, Anxiety, and Insomnia Symptoms in People in Quarantine During the COVID-19 Epidemic

International Journal of Public Health, 2022
Objective: To investigate the status and influential factors of depression, anxiety, and insomnia among people in quarantine during COVID-19.Methods: Data was collected from August 2020 to November 2021 through an online survey of 1,360 people in a ...
Chun Lin, Xiaohong Fu
doaj   +1 more source

National Recovery and Resilience Plan: Latvia

Italian Labour Law e-Journal, 2022
Political leaders and civil society representatives, including the social partners, reached agreement on the main elements to be incorporated in Latvia’s Recovery and Resilience Plan (RRP).
Linda Romele
doaj   +1 more source

Investigation into actions of Xiebai and Zengye decoction on cough sensitivity, airway inflammation and gut microbiota in the rat model of post-infectious cough

Heliyon, 2023
This work was undertaken to observe therapeutic effect of Xiebai and Zengye (XBZY) decoction on post-infectious cough (PIC) in rats, as well as its effect on gut microbiota and the exploration of the intestinal microecological mechanisms of XBZY ...
Jing Luo, Yijue Deng, Yi Ding, Ying Zhang, Min Tan, Guangning Xu, Huining Lin, Mengqing Wang, Chenguang Tang   +8 more
doaj   +1 more source

Insecticide susceptibility status and knockdown resistance (kdr) mutation in Aedes albopictus in China

Parasites & Vectors, 2021
Background Aedes (Stegomyia) albopictus (Skuse, 1894) is the main vector of dengue virus in China. The resistance to insecticides is a huge obstacle for the control of this species, and determining its resistance status and mechanisms in China is ...
Yong Wei, Xueli Zheng, Song He, Xuli Xin, Jiachun Zhang, Ke Hu, Guofa Zhou, Daibin Zhong   +7 more
doaj   +1 more source