Results 91 to 100 of about 5,097,746 (260)

Ubiquitin-specific protease 7 inhibitors reveal a differentiated mechanism of p53-driven anti-cancer activity

iScience
Summary: The USP7 deubiquitinase regulates proteins involved in the cell cycle, DNA repair, and epigenetics and has been implicated in cancer progression. USP7 inhibition has been pursued for the development of anti-cancer therapies.
Alan S. Futran, Tao Lu, Katherine Amberg-Johnson, Jiayi Xu, Xiaoxiao Yang, Saidi He, Sarah Boyce, Jeffrey A. Bell, Robert Pelletier, Takao Suzuki, Xianhai Huang, Heng Qian, Liping Fang, Li Xing, Zhaowu Xu, Stephen E. Kurtz, Jeffrey W. Tyner, Wayne Tang, Tao Guo, Karen Akinsanya, David Madge, Kristian K. Jensen   +21 more
doaj   +1 more source

Non‐Additive Criteria Assessment in Sustainability Evaluation of High Entropy Alloys: A Toxicity‐Weighted Framework

Advanced Engineering Materials, EarlyView.
Sustainability assessment requires methodologies that appropriately distinguish between additive and non‐additive material properties. A toxicity‐weighted scoring system is developed and applied that accounts for the disproportionate influence of highly toxic constituents through nonlinear weighting functions, providing more realistic estimates than ...
Seth Mehalic, Oladele A. Ogunseitan, Julie M. Schoenung   +2 more
wiley   +1 more source

Entropy‐Driven Design of Low‐Melting‐Point Alloys via Compositionally Complex Strategy

Advanced Engineering Materials, EarlyView.
Conventional low‐melting‐point alloys (LMPAs) are limited by a narrow compositional space and inherent property trade‐offs. This review presents an entropy‐driven design strategy that overcomes these limitations, ushering in a new class of low‐melting‐point compositionally complex alloys (LMCCAs).
Yinghui Shang, Jianxiang Zhao, Zhaoqi Chen, Hao Gong, Yinsen Yan, Junlei Tao, Yong Yang   +6 more
wiley   +1 more source

Free trade or protection? which is best off?

Imatge de tres trebaladors britànic, alemany i francés ; Al peu del cartell pastilles de text amb el salari i horari de cada un dels treballadors: "briton, german, frenchman" ; A la part inferior esquerra del cartell: "Nº 11" ; Informació completa al peu

core  

The role of mitochondrial DNA copy number in cardiometabolic disease: a bidirectional two-sample mendelian randomization study

Cardiovascular Diabetology
Background This study used a bidirectional 2-sample Mendelian randomization study to investigate the potential causal links between mtDNA copy number and cardiometabolic disease (obesity, hypertension, hyperlipidaemia, type 2 diabetes [T2DM], coronary ...
Pei Qin, Tianhang Qin, Lei Liang, Xinying Li, Bin Jiang, Xiaojie Wang, Jianping Ma, Fulan Hu, Ming Zhang, Dongsheng Hu   +9 more
doaj   +1 more source

Interval of effective time-step size for the numerical computation of nonlinear ordinary differential equations

Atmospheric and Oceanic Science Letters, 2017
The computational uncertainty principle states that the numerical computation of nonlinear ordinary differential equations (ODEs) should use appropriately sized time steps to obtain reliable solutions.
Jing CAO, Jian-Ping LI, Xin-Yuan ZHANG
doaj   +1 more source

Simulation‐Based Analysis of Insert Pull‐Out in Nickel‐Polyurethane Hybrid Foams Using CT‐Derived Geometries

Advanced Engineering Materials, EarlyView.
CT‐based finite element simulations combined with in situ X‐ray computed tomography are used to analyze insert pull‐out in nickel‐coated polymer foams. Despite variations in material parameters, deformation consistently concentrates within a narrow annular region around the insert.
Yannik Bautz, Jonas Fell, Hendrik Jost, Stefan Diebels, Hans‐Georg Herrmann   +4 more
wiley   +1 more source

Mediterranean diet and dementia: MRI marker evidence from meta-analysis

European Journal of Medical Research
Background Dementia is a growing public health concern with limited effective treatments. Diet may be a modifiable factor that significantly impacts brain health. Mediterranean diet (MeDi) has been suggested to be associated with brain Magnetic Resonance
Xiaojie Wang, Zhiyao Xin, Xiuwen Li, Keying Wu, Wanxin Wang, Lan Guo, Li Wang, Xin Mo, Xinjian Liu, Zhihui Guo, Jing Wang, Ciyong Lu   +11 more
doaj   +1 more source

Radiomics model of CTE can detect inflammatory activity in intestinal Crohn's disease

Meta-Radiology
Objectives: To investigate the diagnostic value of a computed tomography enterography (CTE)-based radiomics model (RM) in the detection of active inflamXGmation in patients with intestinal Crohn's disease (CD).
Jun Jin, Xin Mo, Yi-bo Chen, Jin-bo Cao, Yao-hong Deng, Yu-li Wang   +5 more
doaj   +1 more source

Fabrication Routes for Ionic Conducting Fiber Strain Sensors

Advanced Engineering Materials, EarlyView.
Ionic conducting fiber strain sensors (ICFSs) offer compliant, textile‐integrable sensing. Thus far, the commercialization of ICFSs has been constrained by fiber fabrication routes. This review provides a fabrication‐centric analysis of ICFSs correlating processing strategies with material properties and scalability.
Leo John Kershaw, Zhanhong Yang, Anne Ladegaard Skov, Magdalena Skowyra   +3 more
wiley   +1 more source