Results 41 to 50 of about 5,672,660 (293)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

The current status of primary and secondary school students with myopia in the Shekou district of Shenzhen: a retrospective study

BMC Public Health
Background Myopia is a growing global health issue. This study aims to determine the current status and determinants of primary and secondary school students with myopia in the Shekou District, and to propose reforms in myopia prevention.
Zixuan Xiao, Hui Zhou, Hongmei Wang, Xiaomin Quan, Jianjun Zhang   +4 more
doaj   +1 more source

Identification of Mycobacterium marinum in subcutaneous abscesses of an infected patient's foot

Journal of Infection in Developing Countries
Introduction: Mycobacterium marinum is a well-known pathogenic non-tuberculous mycobacterium for skin and soft tissue infections. Infection, often presenting as superficial lesions, is seen after exposure of skin abrasions to contaminated water or ...
Yong Wei, Jiachun Zhang, Xuli Xin, Yang Wu, Lin Wang, Kai Guo, Yingchun Xu, Song He   +7 more
doaj   +1 more source

Im Zeichen des Wandels – die Europäische Freihandelsassoziation: Ansprüche und Erwartungen an das Top-Verwaltungsmanagement einer internationalen Organisation am Beispiel der EFTA

Yearbook of Swiss Administrative Sciences, 2010
The European Free Trade Association (EFTA) was created in 1960 and is the world’s oldest free trade zone. The importance of EFTA for the remaining Member States (Iceland, Liechtenstein, Norway and Switzerland) has called for higher exigencies to its ...
Doris Leuenberger
doaj   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Effectiveness of photobiomodulation therapy in improving health indicators in obese patients: a systematic review and meta-analysis of RCTs

BMC Complementary Medicine and Therapies
Objective This meta-analysis is aimed to verify the effectiveness and safety of Photobiomodulation (PBM) on body measurements, metabolic indicators, and inflammation indicators in obese patients across randomized controlled trials with various ...
Wenjuan Sun, Zexiang Zhuang, Li Yang, Jie Zhou, Linan Zhang, Junhua Yuan   +5 more
doaj   +1 more source

Labour Standards Provisions in EU Free Trade Agreements: Reflections on the European Commission's Reform Agenda

World Trade Review, 2018
Labour standards provisions within the Trade and Sustainable Development (TSD) chapters of EU Free Trade Agreements (FTAs) are presented as a key element of the EU's commitment to a ‘value-based trade agenda’.
J. Harrison, M. Barbu, Liam Campling, F. Ebert, Deborah Martens, A. Marx, J. Orbie, B. Richardson, Adrian Smith   +8 more
semanticscholar   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source