Results 171 to 180 of about 16,976,330 (240)

Obesity and Age Elevate Tissue-Resident Microbiota Akkermansia muciniphila to Induce Oxidative Stress and Promote Breast Cancer Risk. [PDF]

Cancer Res
Clear KYJ, Arnone AA, Tsai YT, Wilson AS, Carneiro Buchele ML, Furdui CM, Howard-McNatt M, Chiba A, Soto-Pantoja DR, Tooze JA, Peoples A, Duet ML, Katz AJ, Giri DD, Iyengar NM, Cook KL.   +15 more
europepmc   +1 more source

The diagnostic value of the circadian rhythm gene KLF10 in anxiety‐depressive disorders and its neuroimmune regulatory mechanisms

Animal Models and Experimental Medicine, EarlyView.
This graphical abstract illustrates the protective role and molecular mechanism of the circadian rhythm‐related gene KLF10, identified as a diagnostic biomarker and therapeutic target in anxiety‐depressive disorder. Model establishment and phenotypes: An anxiety‐depression model was successfully established by chronic restraint stress combined with ...
Anlan Liu, Weifeng Guo, Jianxiang Li, Tiange Zhang, Dan Xu   +4 more
wiley   +1 more source

From Biological Mechanisms to Task-Oriented Design Principles: A Critical Review of Fish-like Biomimetic Robots. [PDF]

Biomimetics (Basel)
Yan B, Liu H, Tang D.
europepmc   +1 more source

Therapeutic Prospects of Ketamine for Cataplexy in Narcolepsy Type 1: Evidence from a Human Case and a Murine Model

Annals of Neurology, EarlyView.
Narcolepsy type 1 is characterized by cataplexy, for which current treatments targeting monoaminergic, histaminergic, and GABAergic pathways may be ineffective or poorly tolerated. We report the case of a 34‐year‐old man with narcolepsy type 1, intolerant to standard therapies, who experienced marked and sustained cataplexy reduction with morning ...
Francois Ricordeau, Sebastien Arthaud, Leila Langbour, Silvia Melzi, Aurelie Richard‐Mornas, Hannah Doudoux, Benjamin Rolland, Laure Peter‐Derex, Christelle Peyron   +8 more
wiley   +1 more source

Silk Fibroin for Cardiovascular Medical Devices: Review of Material Properties, Applications, and Clinical Potential

Advanced NanoBiomed Research, EarlyView.
Silk fibroin is an attractive natural biomaterial that can be engineered into diverse cardiovascular constructs, including vascular grafts, cardiac patches, heart valves, and stent coatings. Its tunable biological and mechanical properties have driven substantial preclinical progress; however, widespread clinical translation in cardiovascular ...
Mahsa Haghighattalab, Matt Govendir, Kristina Andelovic, Zachary Och, Fatemeh Karimi, Munira Xaymardan, Tomasz Jungst, Jelena Rnjak‐Kovacina, Nona Farbehi   +8 more
wiley   +1 more source

CFD-Guided Shadowing-Aware Acoustic Path Selection for Accurate Wind Estimation in Ultrasonic Anemometers. [PDF]

Sensors (Basel)
Nguyen TMK, Nguyen TD, Vi LTA, Le TD, Nguyen TD, Nguyen MQ, Ahn JS, Nguyen TT, Mondal S, Doan VHM, Choi J, Oh J.   +11 more
europepmc   +1 more source

Intensive versus standard blood pressure control and overall brain small vessel disease burden: a post-hoc analysis of the SPRINT randomized clinical trial. [PDF]

EClinicalMedicine
Charisis S, Pajewski NM, Price LR, Ho NH, Rashid T, Wang D, Zeng Y, Kutty NS, Bryan RN, Kern KC, Dickerson BC, Seshadri S, Nasrallah I, Launer L, Davatzikos C, Williamson JD, Habes M.   +16 more
europepmc   +1 more source

Parametric sweep assessment of cross-slit cylinders for passive drag reduction and wake modification. [PDF]

Sci Rep
Kumar GM, Kumar KM, Mothilal T.
europepmc   +1 more source

In Silico to In Cerebro—Development of the Orexin Receptor Antagonist “Photorexant” for Photomodulation In Vitro and in Mouse Brains

Angewandte Chemie International Edition, EarlyView.
Following a structure‐based design approach, photoswitchable derivatives of the FDA‐approved drug suvorexant were designed, docked, synthesized, and characterized pharmacologically at the orexin 1 and 2 receptors (OX1R and OX2R). Optimized “photorexant” showed up to an 11‐fold difference in IC50 between photoisomers, enabled dynamic and reversible ...
Marcus Angermann, Marie H. Deventer, Vicente Ledesma‐Martin, Nuno Martinho, Alix Flake, Silvia Mori, Angel Nuñez, Jaime Pignatelli, Rita C. Guedes, Christophe P. Stove, Michael Decker   +10 more
wiley   +1 more source