Results 201 to 210 of about 4,703,555 (266)

Barriers and facilitators to dietary change while aiming to reduce free sugar intakes: framework analysis based on intervention, time for change, and success at 12 weeks. [PDF]

J Nutr Sci
Boxall LR, Dalby H, Arden-Close E, James J, Appleton KM.   +4 more
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Brachial Plexus Wrapping by Free Perforator Fat Flap for Treatment of Recurrent Neurogenic Thoracic Outlet Syndrome: A Case Report. [PDF]

Clin Case Rep
Thuau F, Gadbled G, Pradier B, Perrot P, Lancien U.   +4 more
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Recipient Vessel Selection in Free Flap Phalloplasty: A Systematic Review and Single-Arm Meta-Analysis. [PDF]

Microsurgery
Gaston J, Fodor R, Rampazzo A, Fascelli M, Gharb BB.   +4 more
europepmc   +1 more source

Kinematic Strategies of Dragonfly Free-Fall Recovery from an Asymmetric Body Roll. [PDF]

Insects
Shao L, Li H, Zhang J, Wang L.
europepmc   +1 more source

The Role of Flow Couplers in Free Flap Monitoring: Evidence From a Systematic Review and Meta-analysis. [PDF]

Plast Reconstr Surg Glob Open
De Pellegrin L, Dietrich LG, Wölffer M, Olariu R, Zubler C, Lese I.   +5 more
europepmc   +1 more source

A Phase 1, Open-Label, Randomized Study to Investigate the Pharmacokinetics and Safety of Multiple Doses of Intranasal Naloxone in Healthy Participants. [PDF]

Clin Transl Sci
Cassie D, Warnock B, Akhtar F, McCloskey D, Wyatt D.   +4 more
europepmc   +1 more source

From free speech advocates to critics: The Trump administration's new rhetoric promotes support for censorship among Trump voters. [PDF]

Proc Natl Acad Sci U S A
Hall MEK, Leigh BT, Solomon BC.
europepmc   +1 more source