Results 271 to 280 of about 13,970,787 (337)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Pyrotinib or placebo in combination with trastuzumab and docetaxel for HER2 positive metastatic breast cancer: long term survival results from randomised phase 3 PHILA trial.

BMJ
Ma F, Yan M, Li W, Ouyang Q, Tong Z, Teng Y, Wang Y, Wang S, Geng C, Luo T, Zhong J, Zhang Q, Liu Q, Zeng X, Sun T, Mo Q, Zhou S, Li P, Cheng J, Wang X, Nie J, Yang J, Wu X, Wang X, Li H, Yao G, Fan Y, Lin J, Zhu X, Xu B.   +29 more
europepmc   +1 more source

A prescription-free, radiobiology-based framework for automated VMAT planning: A feasibility study in primary prostate cancer radiotherapy. [PDF]

Med Phys
Kuhn D, Spohn SKB, Zamboglou C, Grosu AL, Baltas D, Sachpazidis I.   +5 more
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Smoothness and stability in the Alt-Phillips problem. [PDF]

Math Ann
Carducci M, Tortone G.
europepmc   +1 more source

A nonlocal West Nile virus model with nonlocal free boundary conditions driven by both mosquitoes and birds. [PDF]

J Math Biol
Long X, Lou Y, Ni W, Yi T.
europepmc   +1 more source

Variational free energy as a conceptual framework for understanding habituation in spinal cord stimulation. [PDF]

Front Pain Res (Lausanne)
Taghva A.
europepmc   +1 more source

A numerical study on the effect of laser therapy against port-wine stain by administering artificial red blood cells. [PDF]

Lasers Med Sci
Yoneoka S, Ogo T, Rikihisa N, Hyakutake T.   +3 more
europepmc   +1 more source

Machine learning-enhanced novel design and performance optimization of M₃SbI₃ (M = Ba and Ca) based dual absorber perovskite solar cells. [PDF]

RSC Adv
Hossain MA, Islam MR, Quraishi AM, Gomha SM, Zaki MEA, Rana MM.   +5 more
europepmc   +1 more source