Results 281 to 290 of about 13,850,882 (338)

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

The Three Pillars of ATP Production in Mammalian Sperm: Integrating Gluconeogenesis Into the Metabolic Framework. [PDF]

Reprod Med Biol
Oishi K, Tokito R, Yumura Y, Yoshida M, Yoshida K, Asada M, Mikami K, Watanabe H, Muranishi Y, Kurihara Y.   +9 more
europepmc   +1 more source

Efficacy, safety, and patient-centered outcomes of needle-free injectors versus insulin pens in diabetes management: a comprehensive meta-analysis. [PDF]

Drug Deliv
Wang J, Chen X, Ge Z, Xia Y, Tang Z, Sun Z, Jiao L, Zhou J, Zhang L, Zhao Z.   +9 more
europepmc   +1 more source

A Nanoparticle-Based Strategy to Stabilize 5-Azacytidine and Preserve DNA Demethylation Activity in Human Cardiac Fibroblasts. [PDF]

Pharmaceutics
Kheawfu K, Chittasupho C, Singh S, Okonogi S, Karuna N.   +4 more
europepmc   +1 more source

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Free Will: Responsibility and ‘Free Will’

Royal Institute of Philosophy Lecture Series, 1988
As a rule we treat people as responsible for what they do. We admonish them if they behave badly, praise them if they do well. We punish people. And we reward them.There are exceptions, of course. For example, we do not punish someone for doing something he has been compelled to do, perhaps by having a gun in his back.
openaire   +1 more source