Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
What is the Evolution of Flexible Work in Corporations and What are the Key Trends? [PDF]
, 2017 [Excerpt] Around the world, especially in North America and Europe, businesses are exploring and embracing new ways of bringing flexibility to the workplace.
Chiang, Joey, Lundgren, Andrew
core +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Обекти на езическа култова обредност от римската епоха в Поломието. Част 1
Българско е-Списание за Археология, 2021 Based on the current state of research, this work aims to present, as complete as possible, picture of the pagan cult infrastructure during the Roman period in the Polomie region.
Bilyana Torbatova
doaj
Aspects of Non-Standard Employment in Europe [PDF]
, 2017 [Excerpt] This report investigates recent developments in non-standard employment in the European Union. While the overall policy context is ‘social protection for all’, it does not focus exclusively on social protection.
Eurofound
core +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
The Brighton Fuse 2. Freelancers in the creative digital IT economy [PDF]
, 2015 No description ...
Camerani, Roberto +5 more
core +1 more source
Income and Distribution Analysis with the Taxpayer-Panel - New Prospects and First Results for Self-Employed, as Freelancers and Entrepeneurs, and Employees as Well as for High Incomes [PDF]
This contribution analyzes the personal income distribution with the actual microdata of the German Income Tax Statistics and focus on top incomes for important labour market groups: the self-employed (as freelancers and entrepreneurs) and employees. New
Merz, Joachim, Zwick, Markus
core +1 more source