Results 251 to 260 of about 33,289 (326)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

A Case Report of Giant Congenital Melanocytic Nevus Complicated by Minimal Change Disease, With Genetic Analysis. [PDF]

Clin Case Rep
Yu G, Hu T, Yu T, Zhao Y, Xu X.
europepmc   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

A qualitative study on the post-discharge self-management experiences and needs of patients with secondary lymphedema. [PDF]

Medicine (Baltimore)
Guan Y, Ju H, Xu L, Wan Z, Ge L, Fang Y.
europepmc   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Patients' loyalty to primary care institutions and associated factors in China: a cross-sectional study. [PDF]

BMC Health Serv Res
Li L, Zhang Q, Zhu L, Zeng G, Huang H, Chen Z, Zhou X, Wang X, Xu Z, Wu C, Yang D, Zhai X, Yang S, Lu Z, Gan Y, Lu Z.   +15 more
europepmc   +1 more source

Expectation vs. reality: How stereotypes and expectation disconfirmation affect job evaluations in online labor markets. [PDF]

PLoS One
Tran Nhat D, Teubner T.
europepmc   +1 more source

Six-year retrospective analysis of the epidemiology and risk factors of multidrug-resistant bloodstream infections in oncology patients in Jiangxi, China. [PDF]

Microbiol Spectr
Xu B, Wang X, Li X, Khan MN, Shafiq M, Khan S, Yu T, Khan RU, Song Y, Qiu H, Lv Q-L, Bilal H.   +11 more
europepmc   +1 more source

Knowledge, Attitude, and Practice Toward Spinal Cord Tumors Among Patients and Their Families in Beijing: A Cross-Sectional Study. [PDF]

J Multidiscip Healthc
Liu L, Su Y, Shi L.
europepmc   +1 more source

Gender differences in job satisfaction among gig workers in Bangladesh. [PDF]

Sci Rep
Sarker MR, Taj TA, Sarkar MAR, Hassan MF, McKenzie AM, Al Mamun MA, Sarker D, Bhandari H.   +7 more
europepmc   +1 more source